2型糖尿病血糖波动与认知功能障碍关系的MRI研究进展  

Research progress of MRI on the relationship between blood glucose fluctuations and cognitivedysfunction in type 2 diabetes

作　　者：徐坤[1,2] 王俊 刘光耀[1,3] 张静 XU Kun;WANG Jun;LIU Guangyao;ZHANG Jing(Department of Magnetic Resonance,Lanzhou University Second Hospital,Lanzhou 730030,China;Second Clinical School,Lanzhou University,Lanzhou 730030,China;Gansu Province Clinical Research Center for Functional and Molecular Imaging,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院核磁共振科,兰州730030 [2]兰州大学第二临床医学院,兰州730030 [3]甘肃省功能及分子影像临床医学研究中心,兰州730030

出　　处：《磁共振成像》2023年第10期137-140,146,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81960309);甘肃省科技计划项目(编号:18JR3RA317、21JR7RA438);甘肃省健康产业科学研究项目(编号:GSWSKY2021-031)。

摘　　要：2型糖尿病(type 2 diabetes mellitus, T2DM)是认知功能障碍的高危因素。血糖波动会加剧T2DM患者认知功能障碍的风险。MRI作为一种非侵入性的神经影像学技术,已广泛用于研究T2DM伴有认知功能障碍有关发病机制的研究。本文主要综述T2DM血糖波动与认知功能障碍的MRI研究进展,以阐明血糖波动与认知功能障碍之间的关系,为临床治疗提供靶点。Type 2 diabetes mellitus(T2DM)is one kind of high risk factor of cognitive dysfunction.Fluctuations in blood glucose will increase the risk of cognitive dysfunction in patients with T2DM.MRI,as a non-invasive neuroimaging technique,has been widely used to study the pathogenesis associated with cognitive dysfunction with T2DM.This article mainly reviews the literature on blood glucose fluctuations and cognitive dysfunction in T2DM to clarify the relationship between them,and to provide targets for clinical treatment.

关 键 词：2型糖尿病 血糖波动 认知功能障碍 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R781.64[医药卫生—诊断学] R749[医药卫生—临床医学]