MRI在胰腺癌新辅助治疗疗效评估中的研究进展  

Advances of MRI in evaluating the efficacy of neoadjuvant therapy for pancreatic cancer

作　　者：伏庆琳 陈杰[1] FU Qinglin;CHEN Jie(Department of Radiology,the Third Affiliated Hospital to Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院放射科,常州213003

出　　处：《磁共振成像》2023年第10期177-182,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:81971572)。

摘　　要：新辅助治疗(neoadjuvant treatment, NAT)提高了胰腺癌根治性切除的可能性,有助于改善患者预后。但患者个体间差异导致NAT疗效差别较大,故而早期、准确评价NAT疗效成为胰腺癌研究热点之一。MRI可以从解剖学和功能学角度间接反映肿瘤细胞和微环境的变化,无创评估治疗效果,弥补了其他影像检查技术的不足。本文就常规MRI和功能MRI技术包括扩散加权成像、体素内不相干运动、动态对比增强MRI、T1 mapping、T2 mapping,以及PET/MRI等技术在胰腺癌NAT疗效评估方面的研究现状展开综述,旨在协助临床制订有效的诊治策略;便于临床医生及科研人员更系统全面地理解胰腺癌NAT引起肿瘤微环境变化及其治疗相关反应影像学表现的差异。随着MRI功能序列的发展及多参数MRI研究的推进,未来有望构建一个基于MRI的胰腺癌综合序列评估体系。Neoadjuvant treatment(NAT)improves the possibility of radical resection of pancreatic cancer and can help improve patient outcomes.However,the efficacy of NAT varies greatly among patients due to individual differences.Early and accurate evaluations of the efficacy of NAT has become one of the hotspots in pancreatic cancer.MRI,which can non-invasively evaluate the therapy response,indirectly reflects the changes of tumor cells and microenvironments from a anatomy and function and makes up for the insufficiency of other imaging techniques.This paper reviews the current status of conventional MRI and functional MRI techniques,including diffusion weighted imaging,intravoxel incoherent motion,dynamic contrast enhanced MRI,T1 mapping,T2 mapping and PET/MRI,in evaluating NAT efficacy in pancreatic cancer,so as to assist clinical to develop effective diagnosis and treatment strategies.It is convenient for clinicians and researchers to systematically and comprehensively understand the changes of tumor microenvironment caused by NAT in pancreatic cancer and the differences in imaging findings of treatment-related responses.With the development of functional MRI and the advancement of multi-parameter MRI,The MRI based comprehensive sequence evaluation system for pancreatic cancer is expected to be constructed in the future.

关 键 词：胰腺癌 胰腺恶性肿瘤 磁共振成像 新辅助治疗 疗效评估 预后 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.9[医药卫生—诊断学]