血清E-选择素和LRRFIP1水平对妊娠期高血压孕妇不良分娩结局的预测价值  

The Predictive Value of Serum E-selection and LRRFIP1 Levels for Adverse Delivery Outcome of Pregnant Women withHypertensive Disorder of Pregnancy

作　　者：赵雪莲 杨青 张丽杰 李亚男 单爽 王金玲 ZHAO Xuelian;YANG Qing;ZHANG Lijie;LI Yanan;SHAN Shuang;WANG Jinling(Department of Obstetrics,Maternal and Child Health Hospital of Qinhuangdao,Qinhuangdao 066000,China)

机构地区：[1]秦皇岛市妇幼保健院产科,河北秦皇岛066000

出　　处：《标记免疫分析与临床》2023年第9期1480-1484,共5页Labeled Immunoassays and Clinical Medicine

基　　金：秦皇岛市科学技术研究与发展计划(编号:201902A212)。

摘　　要：目的 探讨妊娠期高血压疾病(HDP)孕妇血清E-选择素(E-selection)、富亮氨酸重复序列相互作用蛋白1(LRRFIP1)水平对不良分娩结局的预测价值。方法 选择2020年6月至2022年6月秦皇岛市妇幼保健院接收的200例HDP孕妇为HDP组,根据疾病严重程度,分为妊娠期高血压组(69例)、子痫前期组(90例)和重度子痫前期组(41例);根据是否发生不良分娩结局,分为分娩不良组(128例)和分娩良好组(72例)。选取同期产检正常者100例为对照组。采用酶联免疫吸附法检测血清E-selection、LRRFIP1水平;采用受试者工作特征曲线分析血清E-selection、LRRFIP1水平对HDP孕妇不良分娩结局的预测价值。结果 HDP组孕妇血清中E-selection水平为55.96±4.08ng/mL、LRRFIP1为7.86±1.29ng/mL,均高于对照组,差异有统计学意义(P<0.05)。妊娠期高血压组、子痫前期组、重度子痫前期组血清E-selection、LRRFIP1水平比较,差异均有统计学意义(P<0.05)。与分娩良好组相比,分娩不良组孕妇血清中E-selection、LRRFIP1水平上升,差异有统计学意义(P<0.05)。与对照组相比,HDP组不良分娩结局的总发生率较高,差异有统计学意义(P<0.05)。血清E-selection、LRRFIP1水平预测HDP孕妇不良分娩结局的曲线下面积(AUC)分别为0.712和0.709,两者联合预测的AUC高于单独预测(Z=5.662、5.828,P<0.05)。结论 HDP孕妇血清E-selection、LRRFIP1水平升高,与HDP病情程度关系密切,均有望作为不良分娩结局的预测因子。Objective To investigate the predictive value of serum E-selection and leucine-rich repeat interacting protein-1(LRRFIP1)levels for adverse delivery outcomes among pregnant women with hypertensive disorder of pregnancy(HDP).Methods A total of 200 HDP pregnant women who visited the Maternal and Child Health Hospital of Qinhuangdao from June,2020 to June,2022 were enrolled as HDP group.According to the severity of the disease,these patients were divided into groups of pregnancy induced hypertension(69 cases),preeclampsia(90 cases)and severe preeclampsia(41 cases).According to the occurrence of adverse delivery outcomes,these patients were divided into the adverse delivery group(128 cases)and good delivery group(72cases).We selected 100 cases of normal postpartum examination during the same period as the control group.Serum E-selection and LRRFIP1 were detected by ELISA;ROC curve was drawn to analyze the predictive value of serum E-selection and LRRFIP1 levels for adverse delivery outcomes of HDP pregnant women.Results Compared with the control group,levels of E-selection(55.96±4.08ng/mL)and LRRFIP1(7.86±1.29ng/mL)in serum of pregnant women in the HDP group were significantly increased(P<0.05).Levels of serum E-selection and LRRFIP1 in the pertensive group during pregnancy,preeclampsia group and severe preeclampsia group were compared,and the difference was statistically significant(P<0.05).Compared with the good delivery group,levels of serum E-selection and LRRFIP1 in the adverse delivery group increased significantly(P<0.05).Compared with the control group,the HDP group had a higher overall incidence of adverse delivery outcomes,and the difference was statistically significant(P<0.05).AUCs predicted by serum E-selection and LRRFIP1 levels for adverse delivery outcomes in HDP pregnant women were 0.712 and 0.709,respectively.The AUC predicted by the combination of the two was significantly higher than that predicted by individual marker(Z=5.662,5.828,P<0.05).Conclusion Elevated levels of serum E-selection and LRR

关 键 词：妊娠期高血压 不良分娩结局 E-选择素 富亮氨酸重复序列相互作用蛋白1 预测 

分 类 号：R714.25[医药卫生—妇产科学]