高龄子痫前期孕妇血AT1-AA、tTG水平变化及对妊娠结局的预测价值探讨  

Changes of Blood AT1-AA and tTG Levels in Older Pregnant Women with Preeclampsia and Their Predictive Values for Pregnancy Outcome

作　　者：单委 冯小丹 朱怡 凌剑梅 SHAN Wei;FENG Xiaodan;ZHU Yi;LING Jianmei(Nantong Maternal and Child Health Care Hospital,Nantong City,Nantong 226001,China)

机构地区：[1]南通市妇幼保健院,江苏南通226001

出　　处：《标记免疫分析与临床》2023年第9期1500-1504,共5页Labeled Immunoassays and Clinical Medicine

基　　金：南通市卫生健康委员会科研课题(编号:QB2021021)。

摘　　要：目的探讨抗血管紧张素II 1型受体自身抗体(AT1-AA)、组织型转谷氨酰胺酶(tTG)在高龄子痫前期(PE)孕妇血液中的表达及对不良妊娠结局的预测价值。方法选择2019年9月至2022年10月在我院就诊的100例高龄PE患者作为研究对象,根据该100例孕妇的妊娠结局将其分为良好组(n=78)及不良组(n=22),另选取同期来我院进行一般体检的50例健康高龄孕妇作为对照组,采用酶联免疫吸附法(ELISA)检测各组孕妇血液中AT1-AA、tTG表达并进行对比;Spearman相关系数分析AT1-AA、tTG表达与高龄PE孕妇不良妊娠结局的相关性;ROC分别分析AT1-AA、tTG联合检测对高龄孕妇发生PE及高龄PE患者发生不良妊娠结局的预测价值。结果3组孕妇血清AT1-AA、tTG表达差异具有统计学意义(P<0.05);Spearman相关系数验证AT1-AA、tTG与高龄PE孕妇发生不良妊娠结局之间呈显著的正相关关系(rs=0.674、0.712,P<0.05);ROC显示AT1-AA、tTG联合检测对预测高龄孕妇是否发生PE的灵敏度为89.00%,特异性为86.00%;对预测高龄PE孕妇不良妊娠结局的发生的灵敏度为86.36%,特异性为91.03%。结论高龄PE孕妇血AT1-AA、tTG呈显著高表达,联合AT1-AA、tTG检测能够有效预测不良妊娠结局的发生。Objective To investigate expressions of autoantibodies to theangiotensin II type 1 receptor(AT1-AA)and tissue transglutaminase(tTG)in the blood of elderly pregnant women with preeclampsia(PE)and their predictive values for adverse pregnancy outcomes.Methods A total of 100 elderly patients with PE who visited our hospital from September,2019 to October,2022 were selected as the study objects.According to the pregnancy outcome,these patients were divided into a good group(n=78)and a poor group(n=22),while Another 50 healthy elderly pregnant women who visited our hospital for general physical examination during the same period were selected as the control group.Expressions of AT1-AA and tTG in the blood of pregnant women were detected by enzyme-linked immunosorbent assay(ELISA)and compared among groups.Spearman correlation coefficient was used to evaluate the correlation among AT1-AA and tTG expressions and adverse pregnancy outcomes in elderly women with PE.ROC curve was drawn to analyze the predictive value of AT1-AA and tTG combined detection for the occurrence of PE in elderly pregnant women and adverse pregnancy outcomes in elderly PE patients.Results There were significant differences in serum AT1-AA and tTG expressions among the three groups(P<0.05).Spearman correlation coefficient showed a significant positive correlation between AT1-AA and tTG and adverse pregnancy outcomes in elderly women with PE(rs=0.674,0.712,P<0.05).ROC curve showed that the sensitivity and specificity of AT1-AA and tTG combined tests for predicting the occurrence of PE in older pregnant women were 89.00%and 86.00%respectively.The sensitivity and specificity were 86.36%and 91.03%for predicting adverse pregnancy outcomes in elderly women with PE.Conclusion The blood AT1-AA and tTG are highly expressed in elderly PE pregnant women,and the combined detection of AT1-AA and tTG can effectively predict the occurrence of adverse pregnancy outcomes.

关 键 词：高龄子痫前期孕妇 抗血管紧张素II 1型受体自身抗体 组织型转谷氨酰胺酶 妊娠结局 预测价值 

分 类 号：R714.25[医药卫生—妇产科学]