β-羟丁酸介导的表观遗传修饰及其调节炎症反应分子机制研究进展  

β-Hydroxybutyrate Mediated Epigenetic Modification and Its Molecular Mechanism of Regulating Inflammation

作　　者：戴伶俐 刘在霞 郭丽丽 杨彦达 常晨城 王宇[4] 石彩霞[1] 王玉珍[2] 张文广[1,2] DAI Lingli;LIU Zaixia;GUO Lili;YANG Yanda;CHANG Chencheng;WANG Yu;SHI Caixia;WANG Yuzhen;ZHANG Wenguang(College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;College of Life Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences,Hohhot 010031,China;College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China)

机构地区：[1]内蒙古农业大学动物科学学院,呼和浩特010018 [2]内蒙古农业大学生命科学学院,呼和浩特010018 [3]内蒙古自治区农牧业科学院,呼和浩特010031 [4]内蒙古农业大学兽医学院,呼和浩特010018

出　　处：《畜牧兽医学报》2023年第10期4095-4104,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：内蒙古自治区直属高校基本科研业务项目(RZ2200001019);内蒙古自治区自然科学基金重大项目(2021ZD05);内蒙古自治区科技计划(2021GG0025,2021GG0008);内蒙古农业大学动物科学学院标志性成果专项资金项目(BZCG201903)。

摘　　要：围产期奶牛经历不同程度的能量负平衡状态,严重的能量负平衡导致奶牛酮病,血液酮体浓度异常升高,降低奶牛的生产性能,并且常发生炎症性疾病。β-羟丁酸(β-hydroxybutyrate,BHBA)是主要的酮体分子,BHBA不仅可以作为能量物质供能,还能够介导表观遗传修饰调控基因转录表达,也能够作为信号分子与相应的受体结合,调控炎症反应。BHBA将外界环境变化与细胞功能改变联系起来,影响疾病进程。本文从BHBA信号传导角度进行综述,重点阐述BHBA影响表观遗传修饰改变基因转录调控,探讨了对炎症反应调节的分子机制,以期为代谢与炎症的研究提供新思路。Dairy cows experience varying degrees of negative energy balance during the perinatal period.Severe negative energy balance leads to ketosis,abnormally elevated blood ketone body concentration,reduced performance,and often inflammatory diseases in dairy cows.β-hydroxybutyrate(BHBA)is a major ketone molecule.BHBA not only acts as an energy source,but also mediates epigenetic modifications that regulate gene transcription and expression,and can act as a signaling molecule that binds to the corresponding receptor to regulate the inflammatory response.BHBA links changes in the external environment to changes in cell function and affects disease processes.This review of BHBA signal transduction focuses on the effect of BHBA on epigenetic modification to alter gene transcription regulation,and explores the molecular mechanisms of BHBA in the regulation of inflammatory response,with the aim of providing new ideas for the study of metabolism and inflammation.

关 键 词：Β-羟丁酸 表观遗传修饰 炎症 代谢 

分 类 号：S852.2[农业科学—基础兽医学]