新生儿败血症并发心肌损害患儿血清miR16-、CF-6、Copeptin水平变化意义  

Changes of serum miR-16,CF-6 and Copeptin levels in children with neonatal sepsis complicated with myocardial damage

作　　者：杨慧洁 刘定远[1] 黄久浪 彭好[1] 罗晓斌[1] YANG Huijie;LIU Dingyuan;HUANG Jiulang;PENG Hao;LUO Xiaobin(Department of Pediatrics,Suining Central Hospital,Suining,Sichuan 629000,China)

机构地区：[1]遂宁市中心医院儿科,四川遂宁629000

出　　处：《国际检验医学杂志》2023年第20期2503-2507,共5页International Journal of Laboratory Medicine

基　　金：四川省卫健委2018年科研课题(18PJ409)。

摘　　要：目的探讨新生儿败血症并发心肌损害患儿血清微小RNA-16(miR-16)、线粒体偶联因子-6(CF-6)、和肽素(Copeptin)水平变化意义。方法将该院2020年1月至2022年9月收治的105例新生儿败血症患儿根据是否并发心肌损害分为心肌损害组(43例)与无心肌损害组(62例),比较两组一般资料、心肌损害标志物心肌肌钙蛋白I(cTnI)、心脏型脂肪酸结合蛋白(H-FABP),以及血清miR-16、CF-6、Copeptin水平,分析各血清指标与心肌损害标志物相关性及对新生儿败血症并发心肌损害的诊断价值,对比心肌损害组不同病情患儿血清miR-16、CF-6、Copeptin水平,分析各血清指标与新生儿败血症并发心肌损害患儿病情的关系。结果心肌损害组败血症严重程度,以及血清cTnI、H-FABP、miR-16、CF-6、Copeptin水平均高于无心肌损害组(P<0.05),心肌损害组血清miR-16、CF-6、Copeptin与cTnI、H-FABP均呈正相关(P<0.05),血清miR-16、CF-6、Copeptin联合诊断新生儿败血症并发心肌损害的曲线下面积(AUC)为0.913(95%CI:0.842~0.959),优于三者单一诊断(P<0.05)。心肌损害组不同心功能分级患儿血清miR-16、CF-6、Copeptin水平由高到低依次为Ⅲ~Ⅳ级、Ⅱ级、Ⅰ级,差异均有统计学意义(P<0.05);心肌损害组有心脏收缩功能障碍患儿血清miR-16、CF-6、Copeptin水平高于无心脏收缩功能障碍患儿(P<0.05);血清miR-16、CF-6、Copeptin与新生儿败血症并发心肌损害患儿心功能分级、心脏收缩功能障碍均呈正相关(P<0.05)。结论血清miR-16、CF-6、Copeptin联合检测可作为新生儿败血症并发心肌损害的重要辅助诊断途径,且三者水平变化与病情严重程度显著相关。Objective To investigate the changes of serum microRNA-16(miR-16),mitochondrial coupling factor-6(CF-6),and Copeptin levels in children with neonatal sepsis complicated with myocardial damage.Methods A total of 105 children with neonatal sepsis admitted to this hospital from January 2020 to September 2022 were divided into myocardial damage group(43 cases)and without myocardial damage group(62 cases)according to whether they had complicated myocardial damage.The general data and myocardial damage markers,cardiac troponin I(cTnI)and cardiac-type fatty acid binding protein(H-FABP)of the two groups were compared,and the serum levels of miR-16,CF-6 and Copeptin were also analyzed.The correlation between serum indexes and markers of myocardial damage and the diagnostic value of neonatal sepsis complicated with myocardial damage were analyzed.The serum levels of miR-16,CF-6 and Copeptin in children with different conditions in the myocardial damage group were compared,and the relationship between serum indexes and the condition of neonatal sepsis complicated with myocardial damage was analyzed.Results The severity of sepsis,serum levels of cTnI,H-FABP,miR-16,CF-6 and Copeptin in myocardium damage group were higher than those in without myocardial damage group(P<0.05).Serum miR-16,CF-6 and Copeptin in myocardium damage group positively correlated with cTnI and H-FABP(P<0.05).The area under the curve(AUC)of serum miR-16,CF-6 and Copeptin in the diagnosis of neonatal sepsis complicated with myocardial damage was 0.913(95%CI:0.842-0.959),which was better than the single diagnosis of the three(P<0.05).The levels of serum miR-16,CF-6 and Copeptin in children with cardiac function gradeⅢto gradeⅣ,gradeⅡand gradeⅠwere successively from high to low,and the differences were statistically significant(P<0.05).The levels of miR-16,CF-6 and Copeptin in the children with systolic dysfunction were higher than those in the children without systolic dysfunction in the myocardial damage group(P<0.05).Serum miR-16,CF-6 and Copepti

关 键 词：新生儿败血症 心肌损害 微小RNA-16 线粒体偶联因子-6 和肽素 

分 类 号：R720.597[医药卫生—急诊医学]