器官芯片联合物联网医学在药物疗效预测中的应用  

Organ-on-a-chip combined with medical internet of things in the application of drug efficacy prediction

作　　者：谢林杉 李泽宁 孙梦婷 周建[1,3,4,5] 宋元林 白春学(综述)[1,3,4,5] 毛红菊 杨达伟(审校)[1,3,4,5,7] XIE Linshan;LI Zening;SUN Mengting;ZHOU Jian;SONG Yuanlin;BAI Chunxue;MAO Hongju;YANG Dawei(Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Fudan University,Shanghai 200030,China;State Key Laboratory of Transducer Technology/Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences,Shanghai 200050,China;Department of Medical Internet of Things(MIOT),Shanghai Respiratory Research Institution,Shanghai 200030,China;Shanghai Key Laboratory of Lung Inflammation and Injury,Shanghai 200030,China;Shanghai Engineer and Technology Research Center of Internet of Things for Respiratory Medicine,Shanghai 200030,China;Shanghai Institute of Infectious Disease and Biosecurity,Shanghai 200030,China;Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital(Xiamen),Fudan University,Xiamen,Fujian 361000,China)

机构地区：[1]复旦大学附属中山医院呼吸与危重症医学科,上海200030 [2]中国科学院上海微系统与信息技术研究所/传感技术联合国家重点实验室,上海200050 [3]上海市呼吸病研究所物联网医学研究室,上海200030 [4]上海市肺部炎症与损伤重点实验室,上海200030 [5]上海呼吸物联网医学工程技术研究中心,上海200030 [6]上海市重大传染病和生物安全研究院,上海200030 [7]复旦大学附属中山医院(厦门)呼吸与危重症医学科,福建厦门361000

出　　处：《国际检验医学杂志》2023年第20期2536-2542,共7页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(82170110);上海市浦江人才项目(20PJ1402400);福建省杰出青年基金项目(2022D014);上海市科学技术委员会基金项目(20DZ2254400,21DZ2200600,20DZ2261200);上海市市级科技重大专项(ZD2021CY001);上海市临床重点专科建设项目(shslczdzk02201)。

摘　　要：随着器官芯片技术的迅猛发展,器官芯片能更好地反映人体或细胞外环境的复杂作用,也可以弥补动物模型与人类在生物学上的差异而导致的结果误差,具有极好的应用前景。“物联网医学”概念的提出,有助于解决先进医疗模式与人力不足和设备资源陈旧之间的矛盾,最终消除“三低、四差、两难”的问题。将物联网医学的概念应用于疾病的诊断和治疗时,在设备和技术方面有一定的要求。文章提出将器官芯片与“物联网医学”相结合应用于医学检验学中,利用器官芯片建立疾病模型,利用物联网医学的云端共享功能,实现多中心的数据共享和实时数据监测,有助于推动疾病诊疗的进展,实现患者个体化精准诊疗的需求。With the rapid development of organ chip technology,organ-on-a-chip technology has been able to better reflect the complex effects of the human body or extracellular environment and its application can compensate for the result errors caused by biological differences between animal models and humans,which has excellent application prospects.The concept of Medical Internet of Things can solve the contradiction between the advanced medical model and the lack of manpower and obsolete equipment resources,and finally eliminate the"three low,four poor,two difficult"problems.When applying the concept of Medical Internet of Things to the diagnosis and treatment of diseases,there are certain requirements in terms of equipment and technology.In this review,the combination of the organ-on-a-chip and Medical Internet of Things in medical laboratory science was proposed,and the organ-on-a-chip was used to establish the disease model and cloud sharing function for Medical Internet of Things in order to realize the multi-center data sharing and real-time data monitoring.This will facilitate the progress of disease diagnosis and treatment,and realize the demand for individualized precise diagnosis and treatment.

关 键 词：微流体 器官芯片 物联网医学 呼吸道疾病 医学检验学 

分 类 号：R318.1[医药卫生—生物医学工程]