线粒体ALDH2在心血管疾病中作用机制的研究进展  

Research progress on the mechanism of mitochondrial ALDH2 in cardiovascular diseases

作　　者：司英丽(综述) 张冬青(审校) SI Yingli;ZHANG Dongqing(Department of Clinical Laboratory,the Fourth Medical Centre,Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]中国人民解放军总医院第四医学中心检验科,北京100048

出　　处：《国际检验医学杂志》2023年第20期2553-2557,共5页International Journal of Laboratory Medicine

摘　　要：心血管疾病是一种由多因素引起的具有高发病率、高死亡率的慢性非传染性疾病。目前已成为人类的首要死亡原因。线粒体乙醛脱氢酶2(ALDH2)是一种广泛存在于哺乳动物体内的醛类氧化还原酶,它可以通过代谢有毒醛类[如乙醛、4-羟基壬烯醛(4-HNE)、丙二醛(MDA)等]、抗氧化应激反应、调控细胞凋亡、保护线粒体功能等途径减轻对心肌细胞的损伤。文章主要对目前有关线粒体ALDH2在心血管疾病中作用机制的研究进行综述,希望为心血管疾病未来的研究提供新的思路和方向。Cardiovascular disease is a chronic non-communicable disease caused by multiple factors with high morbidity and mortality.At present,it has become the leading cause of death in humans.Mitochondrial acetaldehyde dehydrogenase 2(ALDH2)is an aldehyde oxidoreductase that widely exists in mammals.It can reduce the damage to cardiomyocytes by metabolizing toxic aldehydes[such as acetaldehyde,4-hydroxynonenal(4-HNE),malondialdehyde(MDA),etc.],anti-oxidative stress response,regulating cell apoptosis,protecting mitochondrial function and other pathways.This article mainly reviews the current research on the mechanism of mitochondrial ALDH2 in cardiovascular diseases,hoping to provide new ideas and directions for the future research of cardiovascular diseases.

关 键 词：线粒体 乙醛脱氢酶2 4-羟基壬烯醛 心血管疾病 

分 类 号：R543[医药卫生—心血管疾病]