失语患者未激活脑区的任务态功能MRI研究:激活似然性估计的Meta分析  

Task-state functional MRI study of non-activated brain regions in aphasia patients:an activation likelihood estimation meta-analysis

作　　者：刘晓亮 于鑫铭 吕文明 于乔文 康曦之 张良文 LIU Xiaoliang;YU Xinming;LYU Wenming(Department of Neurosurgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250000,China)

机构地区：[1]山东第一医科大学附属省立医院神经外科,济南250000 [2]山东第一医科大学附属省立医院医学影像科,济南250000 [3]山东第一医科大学 [4]青岛大学附属医院青岛肿瘤研究院

出　　处：《临床神经外科杂志》2023年第5期490-496,共7页Journal of Clinical Neurosurgery

基　　金：中国博士后科学基金面上项目(2022M711742);山东省自然科学基金青年项目(ZR2023QH032);山东第一医科大学青年科学基金培育科学计划项目(202201050);山东第一医科大学附属省立医院(山东省立医院)科研孵育基金项目(2021FY032)。

摘　　要：目的探索导致失语稳定出现的未激活脑区。方法收集之前所有失语患者的任务态功能核磁共振研究,将正常对照组及失语患者共同激活的坐标位点剔除,对失语患者未激活的脑区进行激活似然性估计(ALE)Meta分析,得出失语患者稳定未激活的脑区。结果Meta分析的结果揭示了左侧颞上沟(STS)后部及其周围颞上回(STG)和颞中回(MTG)是失语稳定未激活脑区。讨论左侧STS后部及周围STG和MTG作为失语稳定未激活的位点,可作为失语症非侵入性治疗的潜在治疗靶点。Objective To explore the inactive brain regions that lead to stable aphasia.Methods By collecting all previous task-state functional MRI studies of aphasia patients,the coordinates jointly activated in normal control groups and aphasia patients were removed,and then the non-activated brain regions of aphasia patients were conducted meta-analysis to obtain the stable non-activated brain regions of aphasia patients.Results The meta-analysis revealed that left posterior superior temporal sulcus(STS)and its surrounding superior temporal gyrus(STG)and middle temporal gyrus(MTG)were the non-activatied brain regions associated with aphasia.Conclusion As stable non-activated brain regions lead to aphasia,left posterior STS and surrounding STG and MTG provide a potential therapeutic target for noninvasive brain stimulation.

关 键 词：失语 任务态功能核磁共振 META分析 

分 类 号：R445.2[医药卫生—影像医学与核医学]