芪参补气胶囊对肺卫气虚人群的保护作用研究  

Study on the Protective Effects of Qishen Buqi Capsule on People with Lung and Defensive Qi Deficiency

作　　者：崔宇涛 范毓慧[1,3,4] 武嫣斐 袁媛[5] 张萍[6] 徐胜[7] 纪建军 赵茹萍 刘晓节 秦雪梅[1,3,4] CUI Yutao;FAN Yuhui;WU Yanfei;YUAN Yuan;ZHANG Ping;XU Sheng;JI Jianjun;ZHAO Ruping;LIU Xiaojie;QIN Xuemei(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Department of Pharmacy,Bayannur City Hospital,Bayannur 015000,China;Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Shanxi University,Taiyuan 030006,China;Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province,Taiyuan 030006,China;The First Hospital of Shanxi Medical University,Taiyuan 030001,China;The Center for Disease Control and Prevention of Taiyuan,Taiyuan 030012,China,;Guangshengyuan TCM Co,Ltd,Shanxi,Datong 037300,China;Taiyuan Jinyuan District Center for Disease Control and Prevention,Taiyuan 030000,China)

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]巴彦淖尔市医院药剂科,内蒙古巴彦淖尔市015000 [3]山西大学化学生物学与分子工程教育部重点实验室,山西太原030006 [4]山西大学地产中药功效物质研究与利用山西省重点实验室,山西太原030006 [5]山西医科大学第一医院,山西太原030001 [6]太原市疾病预防控制中心,山西太原030012 [7]广盛原中医药有限公司,山西大同037300 [8]太原市晋源区疾控中心,山西太原030000

出　　处：《山西大学学报（自然科学版）》2023年第5期1196-1204,共9页Journal of Shanxi University(Natural Science Edition)

基　　金：山西省教育厅疫情专项;山西省青年科技研究基金(201901D211140);地产中药功效物质研究与利用山西省重点实验室(202105D121009)。

摘　　要：为探究中成药芪参补气胶囊(Qishen Buqi capsule,QSBQ)对肺卫气虚者的保护作用,并明确其对体质的改善作用,本研究使用前瞻性同期对照方法进行临床观察试验。将志愿者分为服药组和疫苗组,服药组口服芪参补气胶囊,疫苗组注射流感疫苗。在社区卫生院进行血压测量,同时采血检测T细胞亚群及免疫球蛋白等免疫指标。主任医师进行诊断并使用量表法评价志愿者的中医证候和偏倚体质改善情况,对检测结果进行统计分析。结果表明,干预4周后,芪参补气胶囊服药组血压波动情况较疫苗组平稳;免疫指标检测结果显示,治疗后疫苗组T细胞和免疫球蛋白的改善较服药组更佳,但组间对比无显著性差异;证候计分显示服药组较疫苗组改善显著,且服药组的体征疗效总有效率和偏倚体质改善率均远高于疫苗组。这些结果说明服用芪参补气胶囊后肺卫气虚人群体质得到明显改善,对各主症和次症亦有显著改善作用,对因体质虚弱造成的反复呼吸道感染有预防和保护作用。In order to demonstrate the protective effects of Qishenbuqi capsules(QSBQ)on individuals with lung and defensive qi de-ficiency,and to assess its impacts on physical fitness,a clinical observation experiment was conducted by using a prospective period control method.Participants in this study were divided into two groups,including a medication group,who received QSBQ capsules orally,and a vaccine group,who received an injection of influenza vaccine.Blood pressure was measured at a community health center and subsets and immunoglobulins of T cells were measured through blood sampling.The participants'Traditional Chinese Medicine(TCM)syndromes and biased physiques were diagnosed and evaluated by chief physicians with a scale.Afterward,statis-tical analysis was performed.The results indicated that after four-week intervention,the fluctuation of blood pressure of individuals with QSBQ capsule was more stable than that with vaccine.Although the improvement of T cells and immunoglobulins in the vac-cine group was better than that in the medication group,no significant difference was observed between the two groups.The syn-drome scores of individuals in the medication group were significantly higher than that in the vaccine group.Likewise,the total ef-fective rate of physical signs and biased constitution improvement rate in the medication group were also significantly higher than those in the vaccine group.These findings suggest that QSBQ capsules can improve the physical constitution of individuals with lung and defensive qi deficiency,and significantly improve their main and secondary symptoms,providing a preventative and protec-tive effect against recurrent respiratory tract infections caused by physical weakness.

关 键 词：芪参补气胶囊 四价流感疫苗 肺卫气虚 免疫改善 体质体征 

分 类 号：R969.4[医药卫生—药理学]