职业性噪声对糖化血红蛋白与糖尿病前期影响  

The effects of occupational noise exposure on glycated hemoglobin and prediabetes

作　　者：戴霞云 殷文军 李济超 张玲 徐甜 沈小丽 李群燕 周胜兰 易桂林 潘志伟 陈振龙 DAI Xiayun;YIN Wenjun;LI Jichao;ZHANG Ling;XU Tian;SHEN Xiaoli;LI Qunyan;ZHOU Shenglan;YI Guilin;PAN Zhiwei;CHEN Zhenlong(Wuhan Prevention and Treatment Center for Occupational Diseases,Wuhan,Hubei 430015,China;不详)

机构地区：[1]武汉市职业病防治院,湖北武汉430015 [2]湖北中烟工业有限责任公司武汉卷烟厂,湖北武汉430048

出　　处：《中国职业医学》2023年第3期274-278,共5页China Occupational Medicine

基　　金：国家自然科学基金(81703203);武汉市卫生健康科研基金资助项目(WG16B08)。

摘　　要：目的探讨职业性噪声接触与糖化血红蛋白(HbA1c)及其定义的糖尿病前期的关系。方法采用判断抽样方法,选择某卷烟厂1181名作业人员为研究对象;按照其噪声接触水平分为对照组、低水平接触组和高水平接触组,分别有236、359和586人。采集其全血检测HbA1c水平,对其工作场所噪声强度进行定点检测。结果3组人群HbA1c水平和糖尿病前期患病率分别比较,差异均无统计学意义(P值均>0.05)。调整研究对象工龄、性别、吸烟、吸烟包年、饮酒和体质量指数等混杂因素后,多重线性回归分析结果显示,高水平接触组人群HbA1c水平高于对照组(P<0.05);多因素logistic回归分析结果显示,高水平接触组人群糖尿病前期的患病风险高于对照组(P<0.05)。结论职业性噪声可能是职业人群HbA1c水平升高和糖尿病前期的危险因素。在职业健康监护工作中,应重视职业性噪声对HbA1c水平的影响。Objective To investigate the relationship between occupational noise exposure and glycated hemoglobin(HbA1c)levels,as well as prediabetes diagnosed by HbA1c.Methods A total of 1181 workers from a cigarette factory were selected as the research subjects using a judgment sampling method.Workers were divided into control,low-level noise exposure and high-level noise exposure groups,consisting of 236,359,and 586 individuals,respectively.The blood sample was collected for HbA1c test and occupation noise exposure intensity in workplace was detected by an area-sampling method.Results There were no statistical significant differences in HbA1c levels and prediabetes prevalence among the three groups of workers(all P>0.05).After adjusting for potential confounding factors such as years of service,gender,smoking,pack-years of smoking,alcohol consumption,and body mass index,multiple linear regression analysis showed that the high-level noise exposure group had higher HbA1c level than the control group(P<0.05).Multivariable logistic regression analysis results showed that the high-level noise exposure group had higher risk of prediabetes compared with the control group(P<0.05).Conclusion Occupational noise exposure could be a risk factor for the increased HbA1c levels and prediabetes incidence among the occupational population.More attention should be paid to the effects of occupational noise exposure on the HbA1c level in occupational health surveillance.

关 键 词：职业性噪声 糖化血红蛋白 糖尿病前期 影响因素 

分 类 号：R135.99[医药卫生—劳动卫生]