顶空气相色谱-质谱联用法检测化学品中挥发性有机组分  

Qualitative analysis of volatile organic components in chemicals using headspace gas chromatography-mass spectrometry

作　　者：蒙瑞波[1] 戎伟丰[1] 胡嘉雯 何嘉恒[1] 袁静 丘静静 林佐侃[1] 张子群[1] 吴邦华[1] MENG Ruibo;RONG Weifeng;HU Jiawen;HE Jiaheng;YUAN Jing;QIU Jingjing;LIN Zuokan;ZHANG Ziqun;WU Banghua(Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangzhou,Guangdong 510300,China)

机构地区：[1]广东省职业病防治院,广东广州510300

出　　处：《中国职业医学》2023年第3期325-329,共5页China Occupational Medicine

基　　金：广东省医学科学技术研究基金(B2023455)。

摘　　要：目的 建立一种适用于化学品中挥发性有机组分的快速定性分析方法。方法 采用顶空气相色谱-质谱联用法,对化学品中苯、1,2-二氯乙烷和正己烷等19种挥发性有机组分进行定性测定,分析不同的取样量、加热温度、加热时间、进样体积对检测结果的影响,以确定样品的最佳处理条件。结果 以设定的色谱条件分析,本方法的最佳样品处理条件为取样品5.0 g于20.0 mL顶空瓶中,于40℃恒温干燥箱中加热30 min,取顶空气体1.00 mL进样。各组分批内与批间相对标准偏差分别为0.00%~21.05%和0.00%~33.33%;样品置密封玻璃容器中,于室温至少可稳定保存60 d。结论 该处理分析方法操作简单,重复性好,稳定可行,适用于化学品中挥发性有机组分的快速定性分析。Objective To establish a rapid qualitative analysis method for volatile organic components in chemicals.Methods Headspace gas chromatography-mass spectrometry was used to qualitatively determine 19 volatile organic components,including benzene,1,2-dichloroethane,and n-hexane,in chemicals.Different sample amounts,heating temperatures,heating times,and sample volumes were analyzed to assess their effects on detection results and optimize sampling conditions.Results Based on the set chromatography,the optimal sampling process of this method was as follows:5.0 g sample in a 20.0 mL headspace bottle,incubated at 40℃for 30 minutes in a constant-temperature drying incubator,and a 1.00 mL headspace gas injection.The within-run and between-run relative standard deviations of all components ranged from 0.00%to 21.05%and 0.00%to 33.33%,respectively.The samples stored in sealed glass containers were stable at ro0m temperature for at least 60 days.Conclusion This method offers simplicity,good reproducibility,and stability,making it suitable for rapid qualitative analysis of volatile organic components in chemicals.

关 键 词：化学品 挥发性有机组分 气相色谱-质谱联用法 顶空分析 定性分析 

分 类 号：R134.4[医药卫生—劳动卫生]