氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎的效果  

Curative effect of ambroxol combined with azithromycin on Mycoplasma pneumoniae pneumonia in children

作　　者：张松林[1] 丁聪[1] 郭燕军 Zhang Songlin;Ding Cong;Guo Yanjun(The Second Division of General Internal Medicine,Children’s Hospital Affiliated of Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院、河南省儿童医院、郑州儿童医院普内科二病区,郑州450000

出　　处：《中国实用医刊》2023年第15期88-91,共4页Chinese Journal of Practical Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20190919)。

摘　　要：目的探讨氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎的效果。方法抽取2020年1月至2022年10月郑州大学附属儿童医院收治的肺炎支原体肺炎患儿80例,按随机数字表法分为对照组与观察组,每组40例。对照组采用阿奇霉素治疗,观察组采用氨溴索联合阿奇霉素治疗。比较两组治疗效果、临床症状恢复情况及不良反应发生情况;比较两组治疗前后血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、肺功能指标[用力肺活量(FVC)、1秒用力呼气容积(FEV1)]。结果观察组总有效率(92.50%,37/40)高于对照组(75.00%,30/40),P<0.05。观察组住院时间、退热时间、咳喘消失时间及啰音消失时间短于对照组(P<0.05)。治疗后,观察组TNF-α、IL-6水平低于对照组,FVC、FEV1高于对照组(P<0.05)。观察组不良反应发生率(10.00%,4/40)与对照组(12.50%,5/40)比较差异未见统计学意义(P>0.05)。结论氨溴索联合阿奇霉素治疗儿童肺炎支原体肺炎可提高临床效果,改善临床症状及炎症反应,提高肺功能,具有用药安全性。Objective To investigate the curative effect of ambroxol combined with azithromycin on Mycoplasma pneumoniae pneumonia in children.Methods A total of 80 children with Mycoplasma pneumoniae pneumonia treated in Children’s Hospital Affiliated of Zhengzhou University from January 2020 to October 2022 were selected,and they were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with azithromycin,and the observation group was treated with ambroxol combined with azithromycin.The clinical effect,recovery of clinical symptoms,and incidence of adverse reactions were compared between the two groups.The levels of serum inflammatory factors,including tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6),and lung function assessed by forced vital capacity(FVC)and forced expiratory volume in 1 second(FEV1)were compared between the two groups before and after treatment.Results The total effective rate of the observation group(92.50%,37/40)was higher than that of control group(75.00%,30/40),P<0.05.The hospitalization time,fever remission time,cough and asthma disappearance time and rales disappearance time in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of TNF-αand IL-6 in the observation group were lower than those in the control group,while the levels of FVC and FEV1 in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(10.00%,4/40)and the control group(12.50%,5/40),P>0.05.Conclusions Ambroxol combined with azithromycin in the treatment of Mycoplasma pneumoniae pneumonia in children can improve the clinical effect,alleviate clinical symptoms and inflammatory reaction,and improve lung function,with drug safety.

关 键 词：肺炎支原体 肺炎 儿童 阿奇霉素 氨溴索 

分 类 号：R725.6[医药卫生—儿科]