阴道微生态环境与人乳头瘤病毒感染的相关性分析  

Correlation Analysis between Vaginal Microecological Environment and Human Papillomavirus Infection

作　　者：张娴[1] 王世军[1] 周莲娥[1] 沈霞光[1] 王肖然[2] 张清泉[1] Zhang Xian;Wang Shijun;Zhou Lian’e;Shen Xiaguang;Wang Xiaoran;Zhang Qingquan(Department of Obstetrics and Gynecology,Xuanwu Hospital of Capital Medical University,Beijing 100053,China;不详)

机构地区：[1]首都医科大学宣武医院妇产科,北京市100053 [2]首都医科大学宣武医院病案统计科,北京市100053

出　　处：《中国病案》2023年第10期104-107,共4页Chinese Medical Record

摘　　要：目的探讨不同种类阴道微生态异常与人乳头瘤病毒(HPV)感染的相关性,为临床预防和治疗HPV感染提供思路,从而减少宫颈癌的发生。方法选取2021年1月1日至2021年12月31日要求进行常规妇科检查的患者共2400例,对其同时进行阴道微生态和HPV检查,按照阴道微生态结果分为微生态正常组864例、乳酸杆菌减少组824例、细菌性阴道病(BV)组392例、念珠菌性外阴阴道炎(VVC)组217例、滴虫性阴道炎(TV)组17例、混合性阴道炎组86例,分别计算每组HPV感染率,并将乳酸杆菌减少组(12.01%)、BV组(24.74%)、VVC组(13.36%)、TV组(11.76%)、混合型阴道炎组(20.93%)的HPV感染率分别与微生态正常组HPV感染率(11.81%)比较,计算其差异是否具有统计学意义,从而判断上述各种类型阴道微生态异常是否影响HPV感染率。结果BV组患者HPV感染率24.74%、混合型阴道炎组患者HPV感染率20.93%,与微生态正常组HPV感染率11.81%比较差异有统计学意义(P<0.05);而乳酸杆菌减少组、VVC组、TV组HPV感染率与微生态正常组HPV感染率比较差异无统计学意义(P>0.05)。结论BV及混合型阴道炎与HPV感染有相关性,BV及混合型阴道炎患者中HPV感染率明显升高,而乳酸杆菌减少、VVC和TV患者中HPV感染率未见明显升高。积极治疗BV及混合型阴道炎有助于预防HPV感染及清除HPV,从而减少宫颈癌的发生。Objectives To explore the correlation between different types of vaginal microecological abnormalities and human papillomavirus(HPV)infection,in order to provide ideas for the clinical prevention and treatment of HPV infection,so as to reduce the incidence of cervical cancer.Methods A total of 2400 patients who required routine gynecological examination from January 1st,2021 to December 31st,2021 were selected,and vaginal microecology and HPV examination were performed simultaneously.According to the results of vaginal microecology,they were divided into normal microecology group(n=864),Lactobacillus reduction group(n=824),bacterial vaginosis(BV)group(n=392),candida vulvovaginitis(VVC)group(n=217),trichomonas vaginitis(TV)group(n=17)and mixed vaginitis group(n=86).The HPV infection rate in each group was calculated.The HPV infection rate of Lactobacilli reduction group(12.01%),BV group(24.74%),VVC group(13.36%),TV group(11.76%)and mixed vaginitis group(20.93%)were compared with the HPV infection rate of the normal microecological group(11.81%),statistical significance was calculated so as to estimate the effect of different kinds of vaginal microecological abnormalities to HPV infection.Results The infection rate of HPV in BV group and mixed vaginitis group was 24.74%and 20.93%,which were significantly different from that in normal microecological group(P<0.05).However,there was no significant difference in HPV infection rate between Lactobacillus reduction group,VVC group,TV group and normal microecological group(P>0.05).Conclusions BV and mixed vaginitis are related to HPV infection,people with BV and mixed vaginitis had higher HPV infection rate than normal,however the infection rate of HPV was not significantly increased in the people with Lactobacillus reduction,VVC and TV.Active treatment of BV and mixed vaginitis was helpful to prevent HPV infection and eliminate HPV,so as to reduce the morbidity of cervical cancer.

关 键 词：阴道微生态 人乳头瘤病毒感染 细菌性阴道病 混合型阴道炎 宫颈癌 

分 类 号：R711[医药卫生—妇产科学]