外用光敏剂光动力疗法治疗光线性角化病的研究进展  

Research Progress of Topical Photosensitizer Photodynamic Therapy of Actinic Keratoses

作　　者：鹿洪艳 李常兴[1] 曾抗[1] LU Hongyan;LI Changxing;ZENG Kang(Department of Dermatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院皮肤科,广东广州510515

出　　处：《皮肤科学通报》2023年第3期286-291,共6页Dermatology Bulletin

基　　金：国家自然科学基金(82073464);广东省自然科学基金(2023A1515010095)。

摘　　要：外用光敏剂光动力疗法(Photodynamic therapy,PDT)是在治疗区域应用光敏剂,暴露于特定波长的光源,并由此形成对非典型角质形成细胞有毒害作用的活性氧,进而选择性破坏病变组织的治疗技术。光动力疗法是一种不断发展的技术,尤其适用皮损面积广泛、多发或不能耐受手术的患者。光动力疗法由于其对病变组织有良好的选择性,对周围正常组织影响小,且痛苦小,不会导致瘢痕形成等优点,已逐渐在临床治疗光线性角化病中广泛应用及推广。本文就外用光敏剂PDT在光线性角化病治疗中的研究进展做一综述。Topical photosensitizer photodynamic therapy(PDT)is a treatment technique based on the application of photosensitizing agents in the treated area,exposure to light sources of specific wavelengths,and the formation of reactive oxygen species that are toxic to atypical keratinocytes,thus selectively destroying the diseased tissue.Photodynamic therapy is an evolving technique that is particularly suitable for patients with extensive lesions,multiple lesions,or patients who cannot tolerate surgery.Photodynamic therapy has been widely used and promoted in the clinical treatment of actinic keratoses due to its good selectivity to pathological tissue,little impact on surrounding normal tissue,little pain,no surgical scar formation and other advantages.This article reviews the research progress of PDT in the treatment of actinic keratoses.

关 键 词：光动力 光线性角化病 治疗 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]