银屑病并发常见皮肤恶性肿瘤的研究现状  

Progress on Common Skin Malignancy Associated with Psoriasis

作　　者：贺旭 毕新岭 陶苏江 HE Xu;BI Xinling;TAO Sujiang(Department of Dermatology,Changhai Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学附属长海医院皮肤科,上海200433

出　　处：《中国皮肤性病学杂志》2023年第7期733-737,共5页The Chinese Journal of Dermatovenereology

基　　金：科技部重点研发计划(2018YFC1705305);上海申康医院发展中心临床三年行动计划资助(SHDC2020CR1014B-04)。

摘　　要：银屑病是一种免疫介导的慢性炎症性疾病,常伴有冠心病、糖尿病、高血脂、高尿酸血症等共病。研究显示银屑病患者伴发皮肤恶性肿瘤风险升高,以鳞状细胞癌为主,而基底细胞癌和黑素瘤等风险相对较低。通过对其并发皮肤恶性肿瘤的危险因素分析发现:既可以与银屑病患者的慢性炎症状态相关,也可能和银屑病的部分治疗方式相关,如光疗、甲氨蝶呤、肿瘤坏死因子抑制剂等对机体具有一定的诱导基因突变或免疫抑制的功能。本文对近年来银屑病患者合并各类皮肤肿瘤的现状、病因和发病机制进行了阐述,并探讨其防治策略。Psoriasis is an immune-mediated chronic inflammatory disease,often accompanied by comorbidities such as coronary heart disease,diabetes,hyperlipidemia and hyperuricemia.Studies have shown that patients with psoriasis have an increased risk of skin malignancies,mainly squamous cell carcinomas,and relatively lower risks of basal cell carcinomas and melanomas.The risk factors are related to the chronic inflammatory condition of lesions,and some of them are related to the treatment methods of psoriasis.For instance,phototherapy,methotrexate,tumor necrosis factor inhibitors could induce gene mutations or produce immunosuppressive effects on the patients.This article reviews the latest advances of the prevalence,etiology and pathogenesis of various skin tumors in psoriasis patients,and discusses the prevention and treatment strategies.

关 键 词：银屑病 共病 皮肤肿瘤 发病机制 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R739.5[医药卫生—临床医学]