温热对免疫系统的影响及其在感染性皮肤病中的应用  

Effect of Hyperthermia on the Immune System and its Application in Infectious Skin Diseases

作　　者：肖海璐 卢彬[2] 马蕾[3] 齐瑞群[1] XIAO Hailu;LU Bin;MA Lei;QI Ruiqun(Department of Dermatology,the First Hospital of China Medical University,Key Laboratory of Immunodermatology,Ministry of Education and NHC,National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases,Shenyang 110001,China;Department of Dermatology,the Affiliated Hospital of Jining Medical University,Jining 272001,China;Department of Dermatology,the Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]中国医科大学附属第一医院皮肤科,国家卫生健康委员会免疫皮肤病学重点实验室,免疫皮肤病学教育部重点实验室,免疫性皮肤病诊疗技术国家地方联合工程研究中心(辽宁),辽宁沈阳110001 [2]济宁医学院附属医院皮肤科,山东济宁272001 [3]滨州医学院附属医院皮肤科,山东滨州256603

出　　处：《中国皮肤性病学杂志》2023年第7期743-747,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(82173401)。

摘　　要：温热对免疫系统的影响是多因素的,可通过热休克蛋白的产生与释放调节免疫,增强和调动免疫应答,进而达到治疗感染性皮肤病的目的。因其疗效与激光、冷冻等传统治疗方式相当,无明显疼痛、具有“远位”治疗作用、复发率低等优势,温热疗法广泛应用于病毒疣的治疗,且在孢子丝菌病、分枝杆菌等皮肤真菌与细菌性感染中亦展开应用。本文总结温热疗法对免疫系统的影响,及其在感染性皮肤病中的应用现状,并对温热疗法在皮肤科领域的应用进行展望。Hyperthermia has a multifactorial effect on the immune system.It can regulate and enhance the immune response through heat shock protein production and release to achieve a cure for infectious skin diseases.Hyperthermia has already been widely applied in viral wart treatment because the efficacy is comparable to that of traditional medical treatments,such as laser or liquid nitrogen cryotherapy,with the advantages of less pain,a “remote” therapeutic effect,and a lower recurrence rate.Additionally,it is applied for skin fungal and bacterial infections,such as sporotrichosis and mycobacterium.The immunologic mechanism of hyperthermia and its application in the field of dermatology are reviewed,and the research trend in hyperthermia is also discussed in this article.

关 键 词：温热 免疫系统 疣 感染 皮肤疾病 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]