FoxO转录因子在皮肤创伤修复及瘢痕演变中的作用  

FoxO Transcription Factor in Skin Wound Repair and Scar Evolution

作　　者：孔艳丽 皮龙泉 李莲花[1] 李初颖 金美彤 罗银利 金哲虎[1] KONG Yanli;PI Longquan;LI Lianhua;LI Chuying;JIN Meitong;LUO Yinli;JIN Zhehu(Department of Dermatology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2023年第7期844-848,共5页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(81960561);吉林省教育厅(吉教科合字[2016]第270号);吉林省科技厅(20160101183JC)。

摘　　要：叉头框(forkhead box,Fox)转录因子中的FoxO亚家族(FoxO1、FoxO3a、FoxO4和FoxO6)广泛存在于真核细胞中,在细胞增殖、凋亡、代谢、衰老、氧化应激和自噬等方面发挥重要作用。FoxO转录因子通过参与调控皮肤炎症、血管生成、再上皮化和组织重塑,在创伤修复及瘢痕演变过程中起着至关重要的作用。本综述结合FoxO的一般生物学特性着重探讨其在皮肤创伤修复及瘢痕形成的最新进展。The Forkhead box(Fox) O subfamily(FoxO1,FoxO3a,FoxO4 and FoxO6) are typically present in eukaryotic cells,belongs to Fox transcription factors.It plays an important role in cell proliferation,apoptosis,metabolism,senescence,oxidative stress and autophagy,etc.FoxO transcription factors play a crucial role in the process of skin wound repair and scar evolution by participating in the regulation of skin inflammation,angiogenesis,re-epithelialization and tissue remodeling.Combined with the general biological properties of FoxO,this review focuses on its latest progress in skin wound repair and scar formation.

关 键 词：叉头框O转录因子(FoxO) 皮肤创伤修复 瘢痕 

分 类 号：R641[医药卫生—外科学] R739.5[医药卫生—临床医学]