桂枝茯苓胶囊治疗子宫内膜异位症的临床研究  

Clinical study of Guizhi Fuling capsule in the treatment of endometriosis

作　　者：金洁琼 王丽先 刘钦文 JIN Jie-qiong;WANG Li-xian;LIU Qin-wen(Department of Gynecology,Qingdao Jiaozhou Central Hospital,Qingdao 266300,Shandong,China)

机构地区：[1]青岛市胶州中心医院妇科,山东青岛266300

出　　处：《川北医学院学报》2023年第10期1421-1424,共4页Journal of North Sichuan Medical College

基　　金：青岛市市级临床重点专科妇产科资助(2022-2024年)。

摘　　要：目的:探究桂枝茯苓胶囊治疗肾虚血瘀型子宫内膜异位症(EMT)的临床研究。方法:以90例EMT患者为研究对象,按照治疗方法不同分为对照组(n=45)和观察组(n=45)。对照组给予常规治疗(孕三烯酮胶囊);观察组给予常规+桂枝茯苓胶囊治疗。治疗3个月后,比较两组患者临床疗效,中医证候积分、血液流变学指标[凝血酶原时间(PT)、血小板计数(PLT)、凝血酶时间(TT)、纤维蛋白原(FIB)]、性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))]水平、血清因子[转化生长因子β(TGF-β1)、前列腺素E_(2)(PGE_(2))、血栓素B_(2)(TXB_(2))]水平。结果:治疗3个月后,观察组总有效率高于对照组(P<0.05);患者中医证候积分、PLT、FIB、FSH、LH、E_(2)、TGF-β1、PGE_(2)及TXB2水平均降低,且观察组低于对照组(P<0.05);PT、TT水平较治疗前均升高,且观察组高于对照组(P<0.05)。结论:桂枝茯苓胶囊治疗EMT效果较好,可改善中医症状及血液流变学指标,降低性激素水平及血清因子水平。Objective:To explore the clinical study of Guizhi Fuling capsule in the treatment of endometriosis(EMT)of kidney deficiency and blood stasis type.Methods:90 patients with EMT were selected and divided into control group(n=45)and observation group(n=45)according to different treatment methods.The control group was given conventional treatment(gestrinone capsule),and the observation group was given conventional treatment and Guizhi Fuling capsule.The clinical efficacy,TCM syndromes scores,hemorheological indicators[prothrombin time(PT),platelet count(PLT),thrombin time(TT),fibrinogen(FIB)],sex hormones[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))]and serum factors[transforming growth factor-β(TGF-β1),prostaglandin E_(2)(PGE_(2)),thromboxane B_(2)(TXB_(2))]after 3 months of treatment were compared between the two groups of patients.Results:After 3 months of treatment,the total effective rate in observation group was higher than that in control group(P<0.05).The scores of TCM syndromes and levels of PLT,FIB,FSH,LH,E_(2),TGF-β1,PGE_(2) and TXB_(2) were reduced compared with those before treatment,and the scores and levels in observation group were lower than those in control group(P<0.05).The PT and TT levels increased compared to before treatment,and the indicators in observation group were longer than those in control group(P<0.05).Conclusion:Guizhi Fuling capsule has significant efficacy in treating EMT.It can improve the TCM symptoms and hemorheological indicators and reduce the levels of sex hormones and serum factors.

关 键 词：子宫内膜异位症 桂枝茯苓胶囊 血液流变学 血清转化生长因子Β 

分 类 号：R711.71[医药卫生—妇产科学] R285.5[医药卫生—临床医学]