多发性大动脉炎患者生活质量现状调查及影响因素分析  

Survey on the current quality of life and analysis of influencing factors in patients with Takayasu arteritis

作　　者：罗家音 李瑞豪 苗雨晴 陈作观 周萌 刁永鹏[1] 李大军[1] 李拥军[1] Luo Jiayin;Li Ruihao;Miao Yuqing;Chen Zuoguan;Zhou Meng;Diao Yongpeng;Li Dajun;Li Yongjun(Department of Vascular Surgery,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Graduate School of Peking Union Medical College&Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院血管外科、国家老年医学中心、中国医学科学院老年医学研究院,100730 [2]中国医学科学院北京协和医学院研究生院,100730

出　　处：《中国心血管杂志》2023年第5期435-440,共6页Chinese Journal of Cardiovascular Medicine

基　　金：中央高水平医院临床科研业务费(BJ-2021-196、BJ-2018-089);吴阶平医学基金会临床科研专项资助基金(320.6750.2021-24-2)。

摘　　要：目的探讨多发性大动脉炎患者生活质量现状及其影响因素,为提高患者的健康生活质量提供参考。方法单中心回顾性研究。根据北京医院多发性大动脉炎注册研究(ChiCTR1800018752)数据库中的资料,对2016年10月至2021年12月的多发性大动脉炎患者进行健康问卷调查。问卷内容包括一般资料、疾病负担以及健康调查简表(SF-36)、欧洲五维健康量表(EQ-5D-5L)两种普适性生活质量量表。采用Cronbach’sα系数和Spearman-Brown系数分别评价SF-36量表的内部一致性和分半信度。采用Spearman相关分析或非参数检验分析生活质量的影响因素。结果共发放问卷120份,回收有效问卷112份,问卷有效回收率为93.3%。SF-36量表总体Cronbach’sα系数为0.87,多发性大动脉炎患者在一般健康状况(55.11±21.63)、精力(61.56±20.94)及精神健康(64.64±21.11)维度得分较低。EQ-5D-5L的视觉模拟标尺得分76.07±20.50,效用指数得分0.86±0.16。头臂型(P<0.01)和广泛型(P<0.01)多发性大动脉炎患者的生活质量得分较胸腹主动脉型低。生活质量各维度得分与多发性大动脉炎症状数量呈负相关(P<0.01),但未发现与性别、年龄、并发症数量、患病年龄、患病时长和手术次数相关。结论SF-36量表评估多发性大动脉炎患者生活质量具有较好的信度。多发性大动脉炎对患者的躯体健康和精神健康均产生显著影响。疾病分型和症状数量是影响患者生活质量的因素。Objective To evaluate current quality of life of patients with Takayasu arteritis and its influencing factors,to provide reference for improving quality of life in these patients.Methods This was a single-center retrospective study.Patients enrolled in the clinical registry study(ChiCTR1800018752)were investigated from October 2016 to December 2021,and were surveyed based on an online health-related questionnaire.The questionnaire includes demographic information,disease burden,and two generic healthy-related quality of life measures(HRQoL),i.e.,36-item short form health survey(SF-36)and five-level EuroQol five-dimensional questionnaire(EQ-5D-5L).Internal validity and split-half reliability for SF-36 were assessed with Cronbach’sαstatistics and Spearman-Brown statistics,respectively.Spearman correlation analysis and non-parameter analysis were used to test potential influencing factors on quality of life.Results Totally,120 questionnaires were sent out and 112 qualified responses were received,resulting in a 93.3%effective recovery rate.The overall Cronbach’sαstatistic was 0.87.Patients with Takayasu arteritis had a lower score in general health(55.11±21.63),vitality(61.56±20.94)and mental health(64.64±21.11)according to SF-36.The mean EQ-VAS(Visual analogue scale)score and utility index for EQ-5D-5L were 76.07±20.50 and 0.86±0.16,respectively.Patients of brachiocephalic type(P<0.01)and diffused type(P<0.01)had lower quality of life scores than those of thoracoabdominal aortic type.There were negative correlations between numbers of symptom and overall quality of life score and scores of it’s subdimensions,whereas no significant correlation was found regarding to gender,age,number of ischemic complications,age at disease occurring,time of disease duration and number of surgeries.Conclusions The SF-36 has a preferable validity for evaluating HRQoL for patients with Takayasu arteritis.Patients with Takayasu arteritis have significantly impaired both physical and mental health.Disease type and number of

关 键 词：多发性大动脉炎 生活质量 健康调查简表 欧洲五维健康量表 患者报告结局 

分 类 号：R543[医药卫生—心血管疾病]