微小RNA-210在缺氧致心血管系统疾病中的研究进展  

Research progress of microRNA-210 in hypoxia induced cardiovascular diseases

作　　者：马明仁 蔡晓庆 张鹏 焦丕奇 赵瑞 王菲 马凌 Ma Mingren;Cai Xiaoqing;Zhang Peng;Jiao Piqi;Zhao Rui;Wang Fei;Ma Ling(Department of Cardiology,the 940 th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院心血管内科,兰州730050

出　　处：《中国心血管杂志》2023年第5期485-489,共5页Chinese Journal of Cardiovascular Medicine

基　　金：甘肃省自然科学基金资助项目(21JR1RA181、GSWSKY2020-01);联勤保障部队第940医院院内项目(2021yxky080)。

摘　　要：微小RNA-210(miR-210)是缺氧高度相关的微小RNA之一,其通过抑制细胞凋亡、促进血管生成、调控红系分化以及参与炎症反应发挥关键调节作用。miR-210启动子区域具有缺氧诱导因子1和核转录因子κB结合位点,该结构使其具有作为缺氧致心血管系统疾病生物标记物的临床应用前景。基于此,本文系统总结miR-210当前研究取得的成果以及存在的局限和挑战,以期为缺氧致心血管系统疾病的防治提供新思路。MicroRNA-210(miR-210)is one of the microRNAs highly related to hypoxia,which plays a key regulatory role by inhibiting apoptosis,promoting angiogenesis,regulating erythroid differentiation,and participating in inflammatory responses.The miR-210 promoter region has the binding site for hypoxia-inducing factor 1 and nuclear transcription factorκB,which makes it promising for clinical application as a biomarker for cardiovascular diseases caused by hypoxia.Based on this,this paper systematically summarizes the achievements of current research on miR-210 as well as the existing limitations and challenges,in order to provide new ideas for the prevention and treatment of cardiovascular diseases caused by hypoxia.

关 键 词：微小RNA-210 缺氧 心血管系统 凋亡 血管生成 红系分化 炎症 

分 类 号：R54[医药卫生—心血管疾病]