烟酰胺单核苷酸在中枢神经系统疾病中的作用研究进展  

Recent advance in role of nicotinamide mononucleotide in central nervous system diseases

作　　者：张春佳 李彦 于艳[2] 白帆[2] 荆瀛黎[2] 杨德刚[3] 高峰[3] 李建军[1] Zhang Chunjia;Li Yan;Yu Yan;Bai Fan;Jing Yingli;Yang Degang;Gao Feng;Li Jianjun(School of Rehabilitation,Capital Medical University,Beijing 100069,China;China Rehabilitation Science Institute,China Rehabilitation Research Center(Beijing Bo'ai Hospital),Beijing 100068,China;Department of Spinal and Neural Functional Reconstruction,China Rehabilitation Research Center(Beijing Bo'ai Hospital),Beijing 100068,China)

机构地区：[1]首都医科大学康复医学院,北京100069 [2]中国康复研究中心(北京博爱医院)中国康复科学所,北京100068 [3]中国康复研究中心(北京博爱医院)脊柱脊髓神经功能重建科,北京100068

出　　处：《中华神经医学杂志》2023年第9期947-952,共6页Chinese Journal of Neuromedicine

基　　金：中央级公益性科研院所基本科研业务费专项资金(2023CZ-3,2022CZ-3)。

摘　　要：烟酰胺单核苷酸(NMN)是烟酰胺腺嘌呤二核苷酸(NAD^(+))转化的重要前体,其可通过提升机体内NAD^(+)水平,促进NAD^(+)在生物过程中的递氢作用,从而促进蛋白、多糖合成,提高物质转运和调控效率,改善代谢功能,尤其是在中枢神经系统疾病中,NMN可通过抗氧化、抗炎、线粒体保护、防止神经元及轴突变性等方式发挥神经保护作用。本文现围绕NMN在常见中枢神经系统疾病中发挥的治疗作用及其神经保护作用机制的研究进展进行综述,以期更深入理解NMN在中枢神经系统疾病中的作用,为预测中枢神经系统疾病治疗靶点、筛选治疗药物提供参考。Nicotinamide mononucleotide(NMN)is an important precursor in conversing nicotinamide adenine dinucleotide(NAD^(+))in the body.By elevating NAD^(+)level in the body,NMN enhances the hydrogen transfer function of NAD^(+)in biological processes,promotes the synthesis of proteins and polysaccharides,improves substance transportation and regulatory efficiency,and enhances metabolic functions.Specifically,in central nervous system disease,NMN exerts neuroprotective effect through antioxidation,anti-inflammation,mitochondrial protection,and prevention of neuronal and axonal degeneration.This review focuses on the therapeutic role of NMN in common central nervous system diseases and their neuroprotective mechanisms,so as to further understand the role of NMN in central nervous system diseases,and provide references for predicting therapeutic targets and screening therapeutic drugs for central nervous system diseases.

关 键 词：烟酰胺单核苷酸 中枢神经系统疾病 神经保护 

分 类 号：R741[医药卫生—神经病学与精神病学]