硬皮病的外科治疗策略  

Surgical strategies for scleroderma

作　　者：秦嘉琦 方斌 何嘉皓 王新涛 李青峰[1] 谢芸[1] Qin Jiaqi;Fang Bin;He Jiahao;Wang Xintao;Li Qingfeng;Xie Yun(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海200011

出　　处：《中华整形外科杂志》2023年第9期1020-1027,共8页Chinese Journal of Plastic Surgery

基　　金：交通大学医学院双百人计划(20191916);上海交通大学医学院附属第九人民医院临床研究助推计划(JYLJ202103);上海市科委项目——上海市整形与修复重建临床医学研究中心(22MC1940300)。

摘　　要：硬皮病是一种涉及多学科治疗的罕见病,药物治疗能部分缓解或终止疾病的进展,但不能逆转病损的组织。近年来硬皮病患者在整形外科求医的比例逐渐增多,随着对脂肪及脂肪干细胞再生作用的认识,医生们发现硬皮病的外科治疗在改善形态的同时,还能逆转病损组织的状态,起到局部治愈或减缓进展的作用。该文简述了硬皮病的病因和分型,分析了硬皮病的治疗现状,重点阐述了硬皮病的外科治疗策略,为硬皮病的临床治疗提供参考。Scleroderma is a rare disease which requires multidisciplinary treatment.Drug-based therapy can partially alleviate or end the progression of the disease,but cannot reverse the lesions that have occurred.Scleroderma patients who seek care in plastic surgery has gradually increased in recent years.With the understanding of the regenerative role of fat and adipose stem cells,physicians have found that surgical treatment of scleroderma can improve morphology while reversing the state of the diseased tissue,acting as a local treatment or slowing progression.This paper briefly described the etiology and classification of scleroderma,analyzed the current status of scleroderma treatment and focused on the surgical treatment strategy of scleroderma,providing guidelines for the surgical management of scleroderma.

关 键 词：硬皮病 外科治疗 自体脂肪移植 肉毒毒素类 再生治疗 

分 类 号：R593.2[医药卫生—内科学] R622[医药卫生—临床医学]