基于可生物降解胶原刺激材料的复合性注射产品的研究进展和临床应用  

Progress and clinical applications of biodegradable collagen stimulator-based compound injectables

作　　者：黄宗霖 刘安娜 胡忠林 单宝珍 韩雪峰 Huang Zonglin;Liu Anna;Hu Zhonglin;Shan Baozhen;Han Xuefeng(Department of Fat Grafting and Body Contouring,Plastic Surgery Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院脂肪整形科,北京100144

出　　处：《中华整形外科杂志》2023年第9期1039-1042,共4页Chinese Journal of Plastic Surgery

摘　　要：随着年龄的增长可出现组织容量丢失,疾病、外伤、手术治疗等也可造成皮肤的凹陷或皱纹,严重影响外观。注射填充物治疗此类外形毁损比外科手术治疗的创伤小、治疗精细度高,广受整形外科医师及患者的喜爱。聚左旋乳酸及聚己内酯等材料是一类可生物降解的合成聚合物,能刺激胶原形成,进而逐渐恢复组织容量,在治疗面部老化改变及人类免疫缺陷病毒相关面部脂肪萎缩方面,展现出良好的增容及面部年轻化效果。该文综述了以可生物降解的胶原刺激材料为基础的复合性注射产品的研究进展和临床应用。Volume loss caused by aging process,diseases,trauma and surgical treatments,could lead to facial depressions,profoundly affecting appearance.Injectable fillers could help to correct this type of disfigurements and are preferred by plastic surgeons and patients due to their quality of minimal invasiveness and better delicateness.Among these fillers,collagen stimulators such as poly-L-lactic acid(PLLA)and polycaprolactone(PCL)are biodegradable synthetic polymers that can stimulate collagen formation and thus gradually restore tissue volume.These polymers have been used worldwide to treat facial aging changes and human immunodeficiency virus-associated facial fat lipoatrophy,demonstrating ideal results in volume enhancement and facial rejuvenation.The progress and clinical applications of compound injectables based on biodegradable collagen stimulators are summarized.

关 键 词：注射剂 面部年轻化 聚左旋乳酸 聚己内酯 高分子填充物 

分 类 号：R622[医药卫生—整形外科] R318.08[医药卫生—外科学]