虫类药治疗抽动障碍配伍规律研究  

Study on Insect-Containing Medicine Dispensing Pattern in the Treatment of Tic Disorder

作　　者：程艳 吕林 孟迪 Cheng Yan;Lyu Lin;Meng Di(Qujing Hospital of Traditional Chinese Medicine,Qujing 655000,China)

机构地区：[1]曲靖市中医医院,云南曲靖655000

出　　处：《亚太传统医药》2023年第10期151-156,共6页Asia-Pacific Traditional Medicine

基　　金：云南省科技计划项目(202101AZ070001-284)。

摘　　要：目的:基于古今医案云平台(V2.3.8)探讨含虫类药处方治疗抽动障碍的配伍规律。方法:通过知网、万方、维普、CBM,检索近10年来有关含虫类药处方治疗抽动障碍的文献。将文献中符合要求的中药处方按照纳入标准和排除标准审核后录入古今医案云平台(V2.3.8)进行数据挖掘分析。结果:共纳入326首处方,涉及中药275味,其中虫类药物共20味。使用频次排前5的虫类药分别为僵蚕、全蝎、龙骨、牡蛎、蝉蜕。根据关联规则分析,常与僵蚕配伍的核心药物有7种,常与全蝎配伍的核心药物有7种,常与龙骨配伍的核心药物有8种,常与牡蛎配伍的核心药物有7种,常与蝉蜕配伍的核心药物有6种。通过聚类分析得到4个新处方。通过复杂网络分析得出治疗抽动障碍的核心药物为天麻、钩藤、茯苓、柴胡、龙骨、牡蛎、石菖蒲、菊花、僵蚕、全蝎、蝉蜕、白芍、甘草。结论:虫类药治疗抽动障碍,仍遵循“肝风内动”的主要病机,在治疗上以平肝熄风为主要治则,常与补虚药、解表药、化痰止咳药、开窍药、安神药相配伍。Objective:Utilizing Ancient and Modern Medical Case Cloud Platform(V2.3.8)to investigate the prescription dispensing trend for insect-containing medications for tic disorder.Methods:Through CNKI,WANFANG,VIP,and CBM,the literature on insect-containing medication prescriptions for tic disorder over the last ten years was looked up.Chinese medicine prescriptions found in the literature that fit the requirements were entered into the Ancient and Modern Medical Case Cloud Platform(V2.3.8)for data mining analysis after being reviewed in accordance with the inclusion and exclusion criteria.Results:There were 326 prescriptions totaling 275 Chinese herbal medications,20 of which were worm-like medications.In order of frequency of usage,the top 5 worm remedies were stiff silkworm,entire scorpion,dragon bone,oyster,and cicada molasses.Six core drugs are frequently combined with cicada molasses,seven core drugs are frequently combined with whole scorpions,eight core drugs are frequently combined with dragon bones,seven core drugs are frequently combined with oysters,and seven core drugs are frequently combined with silkworm,according to the association rule analysis.Four novel prescriptions were obtained using cluster analysis.Asparagus,hooked vine,poria,bupleurum,dragon bone,oyster,calamus,chrysanthemum,stiletto,scorpion,cicada,white peony,and licorice are the main tic disorder treatments identified by complex network analysis.Conclusion:The primary etiology for treating tic disorder with insects is still“internal movement of liver wind”and the major therapeutic goal is to calm the liver and relieve wind.It is frequently combined with symptomatic remedies,orifice opening remedies,phlegm-and cough-relieving remedies,deficiency tonics,and tranquilizers.

关 键 词：抽动障碍 虫类药 数据挖掘 配伍规律 

分 类 号：R282.74[医药卫生—中药学]