血清炎症因子检测对呼吸道细菌感染的诊断价值  

Diagnostic value of serum inflammatory factor detection in respiratory tract bacterial infection

作　　者：杨家斌 YANG Jia-bin(Department of Laboratory,Zhongshan Tanzhou Hospital of Guangdong Province,Zhongshan Guangdong Province 528467,China)

机构地区：[1]广东省中山市坦洲医院检验科,广东中山528467

出　　处：《中国城乡企业卫生》2023年第9期1-4,共4页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的 探究血清C反应蛋白(CRP)、淀粉样蛋白A(SAA)及降钙素原(PCT)的表达水平对呼吸道细菌感染患者的诊断价值,为其临床应用提供参考。方法 选取2018年1月—2021年1月广东省中山市坦洲医院收治的呼吸道细菌感染患者、支原体感染患者、病毒感染患者各30例及同期于该院健康检查者30例,将其分别纳入细菌感染组、支原体感染组、病毒感染组和健康组。比较四组CRP、SAA及PCT的表达水平及三种血清因子检测效果;采取随机数字表法将细菌感染患者分为研究组和对照组各15例,对照组给予常规抗菌治疗,研究组则在监测CRP、SAA及PCT的基础上进行抗菌治疗,比较两组治疗时间。结果 细菌感染组、支原体感染组及病毒感染组CRP、SAA及PCT水平均明显高于健康组,且细菌感染组CRP、SAA及PCT水平明显高于支原体感染组和病毒感染组,差异均有统计学意义(P<0.05)。PCT检测的敏感性、特异性、阳性及阴性预测值均明显高于CRP和SAA,差异均有统计学意义(P<0.05)。细菌感染的患者中,研究组用药时间和住院时间分别为(6.84±1.15)、(9.07±1.41)d,均短于对照组的(12.69±2.26)、(15.32±2.78)d,差异均有统计学意义(t=12.636、10.982,P<0.05)。结论 PCT对于呼吸道细菌感染患者的诊断和鉴别具有更高的准确性,监测CRP、SAA及PCT水平可明显缩短呼吸道细菌感染患者治疗时间,具有较高的临床诊断价值。Objective To explore the diagnostic value of the serum C-reactive protein(CRP),serum amyloid proteinA(SAA)and procalcitonin(PCT)expression levels in patients with respiratory tract bacterial infection,so as to provide reference for its clinical application.Methods A total of 30 patients with respiratory tract bacterial infection,30 patients with mycoplasma infection and 30 patients with virus infection admitted to Zhongshan Tanzhou Hospital of Guangdong Province from January 2018 to January 2021,as well as 30 patients who underwent health examinations in this hospital during the same period were selected as the bacterial infection group,mycoplasma infection group,virus infection group and healthy group.The expression levels of CRP,SAA and PCT in four group and the detection effects of the three serum factors were compared.Using random number table method,bacterial infection patients were divided into study group and control group with 15 cases in each group,the control group was given routine antibacterial treatment,while the study group received antibacterial treatment based on monitoring CRP,SAA and PCT,the treatment times between the two groups were compared.Results The levels of CRP,SAA and PCT in the bacterial infection group,the mycoplasma infection group and the virus infection group were significantly higher than those in the healthy group,and the levels of CRP,SAA and PCT in the bacterial infection group were significantly higher than those in the mycoplasma infection group and virus infection group,and the differences were statistically significant(P<0.05).The sensitivity,specificity,positive and negative predictive values of PCT detection were significantly higher than those of CRP and SAA,and the differences were statistically significant(P<0.05). Among patients with bacterial infection,the medicationand hospitalization times in the study group were(6.84±1.15)and(9.07±1.41)days,respectively,whichwere shorter than those in the control group with(12.69±2.26)and(15.32±2.78)days,and the differenceswer

关 键 词：C反应蛋白 血清淀粉样蛋白A 降钙素原 呼吸道细菌感染 诊断价值 

分 类 号：R446.5[医药卫生—诊断学]