1例铜绿假单胞菌感染患者治疗用药分析  

Analysis of medication for a patient with Pseudomonas aeruginosa infection

作　　者：庄俊雪 李蒙[2] 王华兴 ZHUANG Jun-xue;LI Meng;WANG Hua-xing(Department of Pharmacy,Tianjin Baodi District People's Hospital,(Baodi Clinical College of Tianjin Medical University),Tianjin 301800,China;Department of Pharmacy,General Hospital of Tianjin Medical University)

机构地区：[1]天津市宝坻区人民医院(天津医科大学宝坻临床学院)药剂科,天津301800 [2]天津医科大学总医院药剂科

出　　处：《中国城乡企业卫生》2023年第9期62-65,共4页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：目的 通过对呼吸与危重症医学科收治的1例肺部铜绿假单胞菌感染患者的治疗用药进行分析,探讨针对铜绿假单胞菌感染患者的临床治疗思路以及在铜绿假单胞菌感染患者药物治疗过程中临床药师所发挥的作用。方法 患者入院后,多次痰培养及肺泡灌洗液培养均为多重耐药的铜绿假单胞菌感染,临床医师根据药敏结果选用对抗铜绿假单胞菌的抗菌药物治疗,临床药师通过查阅相关文献的方法,对铜绿假单胞菌的耐药机制进行分析,对患者的抗感染治疗方案提出意见、调整用药。结果 由于铜绿假单胞菌耐药机制复杂,治疗过程中医师采纳临床药师意见及时调整抗感染治疗用药,该患者采用联合抗感染方案,患者情况好转出院。结论 临床药师参与临床治疗用药的选择,协助医师优化并且完善患者的治疗方案,实现药物治疗方案个体化,极大地促进了药物的合理使用与临床治疗效果,提高了临床的治愈率。Objective Through the analysis of the treatment of a patient with pulmonary infection with Pseudomonas aeruginosa admitted to the respiratory and critical illness medical department,the clinical treatment ideas for the patients with Pseudomonas aeruginosa infection and the role of clinical pharmacists in the drug treatment of the patients with Pseudomonas aeruginosa infection were discussed.Methods The patient's multiple sputum cultures and alveolar lavage fluid cultures after admission were all multi drug resistant Pseudomonas aeruginosa infections.The clinicians selected antimicrobial agents against Pseudomonas aeruginosa according to the drug sensitivity results.The clinical pharmacists analyzed the drug resistance mechanism of Pseudomonas aeruginosa by consulting the relevant literature,and put forward opinions on the patient's anti infection treatment plan and adjusted the medication.Results Due to the complex drug resistance mechanism of Pseudomonas aeruginosa,the clinicians adopted the opinions of clinical pharmacists in the treatment process to adjust the anti infection treatment drugs in a timely manner.The patient adopted the combined anti infection scheme,and the patient was discharged from the hospital with improved conditions.Conclusion Clinical pharmacists participated in the selection of clinical treatment drugs,assisted doctors to optimize and improve the treatment plan of patients,realized the individualization of drug treatment plan,grealy promoted the rational use of drugs and clinical treatment effect,and improved the clinical cure rate.

关 键 词：铜绿假单胞菌 耐药机制 阿奇霉素 生物被膜 

分 类 号：R969.3[医药卫生—药理学]