健脾化痰泄浊汤在多囊卵巢综合征中疗效评估  

Evaluation of the therapeutic effect of Jianpi Huatan Xiezhuo Decoction in the treatment of polycystic ovary syndrome

作　　者：汪素卿[1] 李淑萍[1] 从蓉俊[1] WANG Suqing;LI Shuping;CONG Rongjun(Department of Gynecology,Changzhou Hospital of Traditional Chinese Medicine,Changzhou 213003,China)

机构地区：[1]常州市中医医院妇科,江苏常州213003

出　　处：《吉林中医药》2023年第10期1179-1183,共5页Jilin Journal of Chinese Medicine

基　　金：江苏省自然科学基金项目(BK20211057)。

摘　　要：目的 探讨健脾化痰泄浊汤在多囊卵巢综合征中的治疗效果。方法 将2019年3月-2022年3月常州市中医医院妇科门诊就诊的多囊卵巢综合征患者84例,采用随机数字表法分为2组,各42例,对照组采用达英-35治疗,研究组口服达英-35联合健脾化痰泄浊汤治疗。治疗3个月后,比较2组的中医证候积分、睾酮(T)、促黄体生成素/促卵泡生成素(LH/FSH)、胰岛素抵抗指数(HOMA-IR)、葡萄糖耐量试验后血糖水平变化、疗效及不良反应发生率。治疗后随访6个月比较2组妊娠成功率和月经紊乱复发率。结果 治疗后,2组主症积分、次症积分均降低,研究组低于对照组(P<0.05);2组T、LH/FSH均降低,研究组低于对照组(P<0.05);2组SHBG均升高,研究组高于对照组(P<0.05);2组HOMA-IR均降低,研究组低于对照组(P<0.05)。组内比较,治疗后,2组患者服糖后1 h、2 h、3 h血糖水平均逐渐降低,差异有统计学意义(P<0.05);组间比较,治疗后,研究组服糖后1 h、2 h、3 h血糖水平均低于对照组(P<0.05)。研究组临床疗效优于对照组(P<0.05)。2组治疗期间均未出现严重不良反应。随访期内,研究组成功妊娠率高于对照组(P<0.05),月经紊乱复发率低于对照组(P<0.05)。结论 健脾化痰泄浊汤联合达英-35治疗多囊卵巢综合征,有助于改善患者的症状,调节性激素代谢,改善胰岛素抵抗,调整月经周期,提升妊娠率,整体治疗效果及安全性良好。Objective To explore the therapeutic effect of Jianpi Huatan Xiezhuo Decoction in the treatment of polycystic ovary syndrome.Methods From March 2019 to March 2022,84 patients with polycystic ovarian syndrome were treated in the department of gynecology,Changzhou Hospital of Traditional Chinese Medicine.They were divided into two groups by the random number table method,with 42 patients in each group.The control group was treated with Diane-35,while the study group was treated with Diane-35 combined with Jianpi Huatan Jiezhuo Decoction.After 3 months of treatment,the TCM syndrome scores,the testosterone(T),luteinizing hormone/folliclestimulating hormone(LH/FSH),insulin resistance index(HOMA-IR),blood glucose level changes after glucose tolerance test,curative effect and incidence of adverse reaction were compared between the two groups.After a follow-up for 6 months,the pregnancy the success rate and the recurrence rate of menstrual disorders were compared between the two groups.Results After treatment,the scores of major symptoms and secondary symptoms in the two groups were decreased,and the scores in the study group were lower than those in the control group(P<0.05);the levels of T,LH/FSH were both decreased in the two groups,and the study group was lower than the control group(P<0.05);the level of SHBG was both increased in the two groups,and the study group was higher than the control group(P<0.05);the level of HOMA-IR was both decreased in the two groups,and the study group was lower than the control group(P<0.05).An intra-group comparison showed that after treatment,the blood glucose levels of the two groups gradually decreased one hour,two hours,and three hours after taking glucose,with a statistically significant difference(P<0.05).An intra-group comparison showed that after treatment,the blood glucose level in the study group was lower than that in the control group one hour,two hours,and three hours after taking glucose,with a statistically significant difference(P<0.05).The clinical efficacy of the stu

关 键 词：多囊卵巢综合征 健脾化痰泄浊汤 达英-35 性激素 

分 类 号：R588.6[医药卫生—内分泌]