5-氨基乙酰丙酸(5-ALA)的生物学作用及其在动物生产中的应用  

Biological function of 5-aminolevulinic acid(5-ALA)and its application in animals production

作　　者：安玉涵 马伊丹 杨佳 邢笑锟 纪鹏 安清聪[1] AN Yu-han;MA Yi-dan;YANG Jia;XING Xiao-kun;JI Peng;AN Qing-cong

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650051

出　　处：《饲料研究》2023年第19期150-154,共5页Feed Research

基　　金：国家自然科学基金项目(项目编号:32060758)。

摘　　要：5-氨基乙酰丙酸(5-aminolevulinic acid,5-ALA)是四吡咯生物大分子合成酶的前体物质,参与卟啉类化合物的合成,与动物体内血红素的合成及铁的吸收利用密切相关,具有提高细胞的抗氧化能力和机体免疫功能的作用。5-ALA参与植物体内叶绿素的合成,会对光敏素生物合成系统产生影响,具有增强果实着色的作用。5-ALA是光敏剂原卟啉IX(PpIX)生成的前体物质,可以通过血红素生物合成产生原卟啉IX(PpIX),在临床上被用作光检测的光敏剂和癌症光动力疗法(PDT)。文章综述了5-ALA的生物学功能及其在动物中的应用研究进展,以期为5-ALA在畜禽养殖中的进一步应用提供参考。5-ALA is a precursor substance of tetrapyrrole biomolecule synthase,which is involved in the synthesis of porphyrins and is closely related to the synthesis of heme and the absorption and utilization of iron in animals,and has the effect of improving the antioxidant capacity of cells and the immune function of body.5-ALA is involved in synthesis of chlorophyll in plants,which can affect the photosensitive biosynthesis system and enhance fruit coloring.5-ALA is a precursor to the production of the photosensitizer protoporphyrin IX(PpIX),which can be produced by heme biosynthesis and is used clinically as a photosensitizer for light detection and cancer photodynamic therapy(PDT).In the paper,the biological function of 5-ALA and its application in animals are reviewed,in order to provide reference for the further application of 5-ALA in livestock and poultry breeding.

关 键 词：5-氨基乙酰丙酸 原卟啉IX 血红素 叶绿素 动物生产 生物学功能 

分 类 号：S816.7[农业科学—饲料科学]