中等剂量纳布啡联合丙泊酚在无痛人工流产术中的麻醉效果  

Anesthetic effect of middle-dose nalbuphine combined with propofol in painless induced abortion

作　　者：尹青梅[1] 吕建辉[2] Yin Qingmei;Lyu Jianhui(Department of Anesthesiology,Yantai Laiyang Central Hospital,Yantai 265200,China;Department of Oncology,Yantai Laiyang Central Hospital,Yantai 265200,China)

机构地区：[1]烟台市莱阳中心医院麻醉科,烟台265200 [2]烟台市莱阳中心医院肿瘤科,烟台265200

出　　处：《中国实用医刊》2023年第14期49-52,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨中等剂量纳布啡联合丙泊酚在无痛人流术中的麻醉效果。方法抽取2020年1月至2021年12月于烟台市莱阳中心医院自愿行无痛人流术的200例患者作为研究对象。所有患者均采取纳布啡联合丙泊酚进行麻醉,根据纳布啡应用剂量,将接受0.10 mg/kg低剂量纳布啡进行麻醉的66例患者纳入A组,将接受0.15 mg/kg中等剂量纳布啡进行麻醉的67例患者纳入B组,将接受0.20 mg/kg高剂量纳布啡进行麻醉的67例患者纳入C组。记录并比较三组患者麻醉前(T0)、麻醉后5 min(T1)及手术结束即刻(T2)的心率(HR)、平均动脉压(MAP),记录并比较三组苏醒时间、丙泊酚用量及不良反应发生情况。结果T0、T1、T2时,三组HR、MAP比较差异均未见统计学意义(P均>0.05);与同组T0时刻比较,T1、T2时三组MAP均下降,差异有统计学意义(P<0.05)。A组苏醒时间长于B、C组(P<0.05);B组苏醒时间短于C组(P<0.05)。A组丙泊酚用量高于B、C组(P<0.05),而B、C组丙泊酚用量比较差异未见统计学意义(P>0.05)。A、B、C组不良反应发生率分别为6.06%(4/66)、7.46%(5/67)、8.96%(6/67),但组间比较差异未见统计学意义(χ^(2)=0.46,P=0.945)。结论无痛人工流产术中应用中等剂量纳布啡联合丙泊酚,可有效减少丙泊酚使用剂量,且对生命体征影响较小,患者苏醒快,安全性好,可获得较佳麻醉效果。Objective To investigate the anesthetic effect of middle-dose nalbuphine combined with propofol in painless induced abortion.Methods A total of 200 patients who consented to underwent painless abortion in Yantai Laiyang Central Hospital from January 2020 to December 2021 were selected as the research objects.All patients were anesthetized with the combination of nalbuphine and propofol.According to the used doses of nalbuphine,66 patients treated with low-dose nalbuphine(0.10 mg/kg)for anesthesia were included in group A,while 67 patients treated with moderate-dose nalbuphine(0.15 mg/kg)for anesthesia were included in group B,and 67 patients treated with high-dose nalbuphine(0.20 mg/kg)for anesthesia were included in group C.The heart rate(HR)and mean arterial pressure(MAP)of the three groups were recorded and compared before anesthesia(T0),5 minutes after anesthesia(T1)and immediately after operation(T2).The recovery time,propofol dosage and adverse reactions of the three groups were recorded and compared.Results There was no significant difference in HR and MAP among the three groups at T0,T1 and T2(all P>0.05).In intra-group comparison of MAP at T0,the MAP in the three groups decreased at T1 and T2,with a statistical significant difference(P<0.05).The recovery time of group A was significantly longer than that of group B and group C,with a statistical significant difference(P<0.05).The recovery time of group B was shorter than that of group C,with a statistical significant difference(P<0.05).The dosage of propofol in group A was higher than that in group B and group C,with a statistical significant difference(P<0.05);there was no significant difference in propofol dosage between group B and group C(P>0.05).There was no significant difference in the incidence of adverse reactions among group A(6.06%,4/66),group B(7.46%,5/67),and group C(8.96%,6/67),χ^(2)=0.46,P=0.945.Conclusions The use of moderate-dose of nalbuphine combined with propofol in painless induced abortion can effectively reduce the dose of propofo

关 键 词：丙泊酚 纳布啡 无痛人流术 苏醒时间 麻醉效果 不良反应 

分 类 号：R614[医药卫生—麻醉学]