基于数据挖掘的国医大师丁樱治疗小儿肾病综合征用药规律研究  

Study on National TCM Master Ding Ying’s Medication Law in Treatment of Children with Nephrotic Syndrome Based on Data Mining

作　　者：郑肖庆 张博[1,2] 高敏[1] 申文楠 刘佳佳 丁樱(指导)[1,2] ZHENG Xiaoqing;ZHANG Bo;GAO Min;SHEN Wennan;LIU Jiajia;DING Ying(Medical College of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学儿科医学院,河南郑州450000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《中国中医药信息杂志》2023年第11期46-51,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国医大师传承工作室建设项目(2022年);第七批全国老中医药专家学术经验继承项目(2022年);中国民族医药学会科研项目(Z1184-400612)。

摘　　要：目的挖掘国医大师丁樱教授治疗小儿肾病综合征的用药规律,探析其治疗本病的学术思想与临床经验。方法选取2013年1月-2020年1月丁樱教授治疗小儿肾病综合征处方,采用FangNet平台,多维度分析处方药物的性味归经、核心处方及药物群组。结果共纳入患儿66例,涉及205诊次,处方205首,中药99种,总频次为3017。中药以性寒、味甘为主,归经以肺经为主。药物权重等级分析显示,黄芪、菟丝子、当归、太子参、黄芩、桑寄生、连翘、生地黄、知母、肉苁蓉、甘草为核心处方。药物-药物共现性分析显示,桑寄生-太子参、黄芩-太子参、黄芩-桑寄生等为常用药对;聚类分析显示10个潜在药物群,体现了丁樱教授重视益气养阴清热、活血化瘀的治法。结论丁樱教授治疗小儿肾病综合征首辨标本、分期论治,以“扶正祛邪,序贯辨治”的临床思想为主线,活血化瘀贯穿治疗始终。Objective To clarify national TCM master Ding Ying’s medication law in the treatment of children with nephrotic syndrome(NS);To elucidate her academic thoughts and clinical experience in the treatment of children with NS.Methods The prescriptions for the treatment of children with NS by Professor Ding Ying from January 2013 to January 2020 were collected.FangNet platform was used to analyze the properties and tastes,meridians,core prescription and drug group of the prescriptions in a multidimensional manner.Results Totally 66 patients were included in the study,involving 205 visits and 205 prescriptions,99 kinds of Chinese materia medica,with a total frequency of 3017.Most kinds of Chinese materia medica were cold in property and sweet in taste.The meridian was mainly lung meridian.Herb rankings showed that Astragali Radix,Cuscutae Semen,Angelicae Sinensis Radix,Pseudostellariae Radix,Scutellariae Radix,Taxilii Herba,Forsythiae Fructus,Rehmannize Radix,Anemarrhenae Rhizoma,Cistanches Herba,and Glycyrrhizae Radix et Rhizoma were core prescriptions.Analysis on herb-herb co-occurrence showed that Taxilii Herba-Pseudostellariae Radix,Scutellariae Radix-Pseudostellariae Radix,Scutellariae Radix-Taxilii Herba were the common drug pairs.Clustering analysis showed 10 potential drug groups,which reflected Professor Ding Ying’s emphasis on nourishing qi and tonifying yin,clearing heat,promoting blood circulation and resolving stasis.Conclusion Professor Ding Ying’s treatment of children with NS is based on the first differentiation of root cause and symptoms and uses phased treatment,with the clinical concept of“supporting the healthy qi and eliminating pathogenic factors,and sequential differentiation and treatment”as the main line,promoting blood circulation and resolving stasis throughout the treatment.

关 键 词：丁樱 儿童 肾病综合征 数据挖掘 用药规律 FangNet平台 

分 类 号：R2-05[医药卫生—中医学] R272.969.2