糖皮质激素联合标准四联抗结核疗法对结核性胸膜炎患者的影响  

Effect of Glucocorticoid Combined with Standard Quadruple Anti-tuberculosis Therapy on Patients with Tuberculous Pleurisy

作　　者：闫雨 段洋洋 鲁潇 YAN Yu;DUAN Yangyang;LU Xiao(Nanyang Central Hospital,Henan Nanyang 473000)

机构地区：[1]南阳市中心医院,河南南阳473000

出　　处：《深圳中西医结合杂志》2023年第15期115-117,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探究糖皮质激素联合标准四联抗结核疗法对结核性胸膜炎患者胸水吸收时间的影响。方法:选取南阳市中心医院2019年3月至2021年2月期间接收的98例结核性胸膜炎患者,随机分为对照组和观察组,各49例。对照组患者采用标准四联抗结核疗法进行治疗,观察组患者采用糖皮质激素联合标准四联抗结核疗法进行治疗,比较两组患者的临床疗效、临床症状恢复情况、胸腔积液细胞炎症因子及不良反应。结果:观察组患者总有效率为97.96%,高于对照组的83.67%,差异具有统计学意义(P<0.05);观察组患者住院、全身中毒症状缓解及胸腔积液吸收时间均短于对照组,差异具有统计学意义(P<0.05);治疗后,观察组患者胸腔积液白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平低于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:糖皮质激素联合标准四联抗结核疗法治疗结核性胸膜炎患者,可缓解患者的炎症,加速胸水吸收率,改善患者临床症状,缩短治疗时间。Objective To explore the effect of glucocorticoid combined with standard quadruple anti-tuberculosis therapy on the time of pleural fluid absorption in patients with tuberculous pleurisy.Methods Ninety-eight patients with tuberculous pleurisy admitted to Nanyang Central Hospital from March 2019 to February 2021 were randomly divided into a control group and an observation group,with 49 cases in each group.The control group was treated with standard quadruple anti-tuberculosis therapy,and the observation group was treated with glucocorticoid combined with standard quadruple anti-tuberculosis therapy.The clinical efficacy,recovery of clinical symptoms,inflammatory factors of pleural effusion and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.96%,which was higher than that of the control group(83.67%),and the difference was statistically significant(P<0.05).The time of hospitalization,relief of systemic poisoning symptoms and absorption of pleural effusion in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of plearal effusion interleukin-6(IL-6)and interleukin-8(IL-8)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of tuberculous pleurisy patients,glucocorticoid combined with standard quadruple anti-tuberculosis therapy can alleviate the inflammatory symptoms of patients,accelerate the absorption rate of pleural fluid,improve the clinical symptoms of patients,and shorten the treatment time.

关 键 词：结核性胸膜炎 标准四联抗结核疗法 糖皮质激素 

分 类 号：R561.1[医药卫生—呼吸系统]