氯沙坦钾联合氨氯地平治疗老年原发性高血压病合并高尿酸血症患者的临床疗效  

Clinical efficacy of losartan potassium combined with amlodipine in the treatment of elderly essential hypertension patients complicated with hyperuricemia

作　　者：林秀清 杨琼花 郑芬 LIN Xiuqing;YANG Qionghua;ZHENG Fen(Pharmacy,the Third People′s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China)

机构地区：[1]福建中医药大学附属第三人民医院西药房,福州市350108

出　　处：《临床合理用药杂志》2023年第24期5-8,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察氯沙坦钾联合氨氯地平治疗老年原发性高血压病合并高尿酸血症患者的临床疗效。方法选取2022年1月—2023年1月福建中医药大学附属第三人民医院收治的老年原发性高血压病合并高尿酸血症患者100例,采用随机数字表法分为氨氯地平组与联合治疗组,各50例。氨氯地平组给予苯磺酸氨氯地平片治疗,联合治疗组在氨氯地平组基础上加用氯沙坦钾片治疗,2组均治疗2个月。比较2组临床疗效,治疗前与治疗2个月后血压(收缩压、舒张压)、颈动脉损伤面积、外周血内皮祖细胞数目、血尿酸及血清炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]水平及不良反应。结果联合治疗组临床总有效率为98.00%,高于氨氯地平组的84.00%(χ^(2)=4.396,P=0.036)。治疗2个月后,2组收缩压、舒张压低于治疗前,颈动脉损伤面积小于治疗前,外周血内皮祖细胞数目多于治疗前,且联合治疗组变化幅度大于氨氯地平组(P<0.01);2组血尿酸及血清hs-CRP、TNF-α、IL-6水平均降低,且联合治疗组低于氨氯地平组(P<0.01)。联合治疗组不良反应总发生率与氨氯地平组比较,差异无统计学意义(2.00%vs.6.00%,χ^(2)=0.260,P=0.610)。结论针对老年原发性高血压病合并高尿酸血症患者,予以氯沙坦钾联合氨氯地平治疗可提高治疗总有效率,降低血压及血尿酸水平,减轻炎性反应,且具有一定的安全性。Objective To observe the clinical efficacy of losartan potassium combined with amlodipine in the treatment of elderly essential hypertension patients complicated with hyperuricemia.Methods One hundred cases of elderly essential hypertension patients complicated with hyperuricemia admitted to the Third People′s Hospital of Fujian University of Traditional Chinese Medicine from January 2022 to January 2023 were selected,and they were divided into the amlodipine group and the combination group by random number table method,50 cases in each group.Patients in the amlodipine group were treated with amlodipine besylate tablets,and patients in the combination group were treated with losartan potassium tablets on the basis of the amlodipine group,both groups were treated for 2 months.Clinical efficacy,blood pressure(systolic blood pressure and diastolic blood pressure),carotid artery injury area,endothelial progenitor cell count in peripheral blood and serum uric acid and inflammatory factors(hs-CRP,TNF-α,IL-6)levels before and after 2 months of treatment,and adverse reactions were compared between the two groups.Results The total clinical effective rate in the combination group was 98.00%,which was higher than 84.00%of the amlodipine group(χ^(2)=4.396,P=0.036).After 2 months of treatment,the systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment,carotid artery injury area was smaller than that before treatment,and endothelial progenitor cell count in peripheral blood was more than that before treatment,and the change in the combination group was greater than that in the amlodipine group(P<0.01);Serum uric acid,hs-CRP,TNF-αand IL-6 levels in the two groups were reduced,and the combination group were lower than those of the amlodipine group(P<0.01).The overall incidence of adverse reactions in the combination group was not statistically significant compared with that in the amlodipine group(2.00%vs.6.00%,χ^(2)=0.260,P=0.610).Conclusion For elderly essential hyper

关 键 词：原发性高血压病 高尿酸血症 老年人 氯沙坦钾 氨氯地平 炎性因子 治疗结果 

分 类 号：R544.11[医药卫生—心血管疾病] R589.7[医药卫生—内科学]