氨氯地平联合替米沙坦治疗老年高血压的效果及对患者血压变异性及血压达标率的影响  

Effect of amlodipine combined with telmisartan in the treatment of elderly hypertension and its influence on blood pressure variability and blood pressure compliance rate of patients

作　　者：林娟 邱艳 陈辉阳 LIN Juan;QIU Yan;CHEN Huiyang(General Medicine Department,Zhangzhou Municipal Hospital of Fujian Province,Fujian Province,Zhangzhou 363000,China)

机构地区：[1]福建省漳州市医院全科医学科,363000

出　　处：《临床合理用药杂志》2023年第28期1-4,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察氨氯地平联合替米沙坦治疗老年高血压的效果及对患者血压变异性及血压达标率的影响。方法选取2022年1—12月福建省漳州市医院全科医学科收治的老年高血压患者76例,采用“红白球法”随机分为观察组和对照组,每组38例。对照组患者采取常规降压管理和治疗,观察组在对照组基础上采用苯磺酸氨氯地平片联合替米沙坦片治疗,2组均持续治疗6个月。比较2组患者治疗效果,治疗前后血压变异性(24 h收缩压与舒张压变异系数)、降压情况(白昼血压、夜间血压、晨峰血压及24 h平均血压),血压达标率及不良反应。结果观察组患者治疗总有效率为92.11%,高于对照组的73.68%(χ^(2)=4.547,P=0.033)。治疗6个月后,2组患者24 h收缩压与舒张压变异系数较治疗前减小,且观察组小于对照组(P<0.01);2组患者白昼、夜间、晨峰收缩压与舒张压和24 h平均收缩压与舒张压较治疗前下降,且观察组低于对照组(P<0.01)。治疗6个月,观察组患者血压达标率为92.11%,高于对照组的73.68%(χ^(2)=4.547,P=0.033)。观察组与对照组不良反应总发生率比较差异无统计学意义(7.89%vs.5.26%,P=1.000)。结论在常规降压管理和治疗基础上给予氨氯地平联合替米沙坦治疗老年高血压的效果显著,可明显改善患者血压变异性和24 h平均血压,降压效果更明显、血压控制更平稳,提高血压达标率,且不良反应较少。Objective To observe the effect of amlodipine combined with telmisartan in the treatment of elderly hypertension and its influence on blood pressure variability and blood pressure compliance rate of patients.Methods A total of 76 elderly patients with hypertension admitted to the General Medicine Department of Zhangzhou Municipal Hospital of Fujian Province from January to December 2022 were selected and they were randomly divided into observation group and control group used"red-white ball method",with 38 cases in each group.The control group was treated with conventional antihypertensive management and treatment,while the observation group was treated with amlodipine besylate tablets combined with telmisartan tablets on the basis of the control group,two groups were treated for 6 months.The treatment effect,blood pressure variability(24 h SBPV,24 h DBPV),blood pressure reduction(daytime blood pressure,nighttime blood pressure,morning peak blood pressure,24 h average blood pressure),blood pressure compliance rate beforeand after treatment,and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 92.11%,was higher than 73.68%in the control group(χ^(2)=4.547,P=0.033).After 6 months of treatment,24 h SBPV and 24 h DBPV in the two groups decreased compared with those before treatment,and the observation group were less than those of the control group(P<0.01);The daytime blood pressure,nighttime blood pressure,morning peak blood pressure,and 24 h average SBP,DBP of the two groups were decreased compared with those before treatment,and the observation group were lower than those of the control group(P<0.01).After 6 months of treatment,the blood pressure compliance rate in the observation group was 92.11%,was higher than 73.68%in the control group(χ^(2)=4.547,P=0.033).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(7.89%vs.5.26%,P=1.000).Conclusion On the basis of conventi

关 键 词：高血压 老年人 氨氯地平 替米沙坦 血压变异性 血压达标率 

分 类 号：R544.1[医药卫生—心血管疾病]