胶原酶化学溶解术微创介入治疗的历史回顾与发展  

History review and development of minimally invasive interventional therapy with collagenase chemonucleolysis

作　　者：史小花 吕卓敏 胡龙泉 李波 张洪新 袁鹏 SHI Xiaohua;LYU Zhuomin;HU Longquan;LI Bo;ZHANG Hongxin;YUAN Peng(Graduated Affairs Office,Xi'an Medical University,Xi'an 710021,China;Department of Nuclear Medicine,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China;Department of Interventional Radiology and Pain,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China;Department of Burns and Plastic Surgery,Tangdu Hospital,Air Force Medical University,Xi'an 710038,China;Medical Unit,No.94259 Troops of PLA,Yantai 265600,China)

机构地区：[1]西安医学院研究生工作部,陕西西安710021 [2]空军军医大学唐都医院核医学科,陕西西安710038 [3]空军军医大学唐都医院介入疼痛科,陕西西安710038 [4]空军军医大学唐都医院烧伤整形科,陕西西安710038 [5]解放军第94259部队卫生队,山东烟台265600

出　　处：《空军军医大学学报》2023年第10期1006-1010,共5页Journal of Air Force Medical University

基　　金：国家自然科学基金(81802345,82172922,81772934);中国博士后科学基金(2020T130787,2019M663984);陕西省自然科学基础研究计划面上项目(2023-JC-YB-671);空军军医大学唐都医院国家自然科学基金助推项目(2021ZTXM-002);空军军医大学唐都医院科技创新发展基金(2019JSYJ005);空军军医大学唐都医院振翅计划人才资助项目(2021ZCJHYP)。

摘　　要：腰椎间盘突出症(LDH)引起的腰腿痛不仅影响患者正常的工作和休息,长期疼痛还会使患者产生不同程度的心理疾病。因此,缓解患者的痛苦并改善其生活质量是治疗的根本目的。胶原酶化学髓核溶解术在LDH治疗中的应用较早,随着其技术不断优化和发展,为患者带来了很好的临床效益。本文主要回顾并分析其在国内外的历史起源、发展历程及应用现状,并对其未来发展做出展望,以期为LDH的临床治疗提供参考。Lumbar and leg pain caused by lumbar disc herniation(LDH)not only affects the normal work and rest of patients,but also causes mental illness to varying degrees.Therefore,the fundamental purpose of treatment is to relieve the pain of patients and improve their quality of life.Collagenase chemonucleolysis has been applied in the treatment of LDH earlier,and with the continuous optimization and development of its technology,it has brought good clinical benefits for patients.This paper mainly reviews and analyzes its historical origin,development course and application status at home and abroad,so as to provide reference for the clinical treatment of LDH.

关 键 词：腰椎间盘突出症 胶原酶化学溶解术 微创治疗 

分 类 号：R687.3[医药卫生—骨科学]