绝经后女性甲状腺功能亢进与骨密度的相关性分析  

Correlation Analysis of Hyperthyroidism and Bone Mineral Density in Postmenopausal Women

作　　者：李烨[1,2] 虞艳芳 陈斌[3] 苏恒 Li Ye;Yu Yanfang;Chen Bin;Su Heng(Department of Pharmacy,The First People's Hospital of Yunnan Province,Kunming 650032,China;Department of Pharmacy,Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032,China;Department of Endocrinology and Metabolism,The First People's Hospital of Yunnan Province,Kunming 650032,China)

机构地区：[1]云南省第一人民医院药学部,昆明650032 [2]昆明理工大学附属医院药学部,昆明650032 [3]云南省第一人民医院内分泌代谢科,昆明650032

出　　处：《大理大学学报》2023年第10期85-89,共5页Journal of Dali University

基　　金：云南省医学领军人才项目(L-201624);云南省万人计划名医专项(YNWR-MY-2019-020);云南省教育厅科学研究基金项目(2021J0009)。

摘　　要：目的:探讨绝经后女性甲状腺功能亢进与各部位骨密度的相关性。方法:选取2021年10月至2022年4月在云南省第一人民医院就诊的220例绝经后女性作为研究对象,比较所有受试者的骨密度值和甲状腺功能指标水平,并按病程长短将甲状腺功能亢进症患者分成不同亚组,比较亚组间骨密度值测量情况。结果:甲状腺功能亢进症患者腰椎、股骨颈、Wards三角、大粗隆、全身的骨密度值显著低于非甲状腺功能亢进症者,病程≥1年的甲状腺功能亢进症患者腰椎骨密度值显著低于病程<1年者(P<0.05);游离三碘甲状腺原氨酸(FT3)水平与股骨颈、Wards三角和全身骨密度值呈负相关,游离甲状腺素(FT4)水平与Wards三角骨密度值呈负相关。结论:绝经后甲状腺功能亢进女性的骨密度值显著低于绝经后非甲状腺功能亢进女性,病程延长更容易导致腰椎骨密度值下降,FT3、FT4水平与骨密度值呈负相关。Objective:To explore the correlation between hyperthyroidism and bone mineral density(BMD)in postmenopausal women.Methods:A total of 220 postmenopausal women who visited the First People's Hospital of Yunnan Province from October 2021 to April 2022 were selected as the study subjects.BMD and thyroid function indicators were compared among all participants.The patients with hyperthyroidism were divided into different subgroups according to the duration of the disease,and BMD measurements were compared among the subgroups.Results:The BMD values of lumbar vertebra,neck of femur,Wards triangle,greater trochanter and the whole body in patients with hyperthyroidism were significantly lower than in those without hyperthyroidism.Among patients with hyperthyroidism,those with a disease duration of≥1 year had significantly lower BMD values in the lumbar spine compared to those with a disease duration of<1 year(P<0.05).The levels of free triiodothyronine(FT3)were negatively correlated with BMD values in the neck of femur,Wards triangle,and the whole body,while the levels of free thyroxine(FT4)were negatively correlated with BMD values in Wards triangle.Conclusion:The BMD values of postmenopausal women with hyperthy-roidism are significantly lower than those without hyperthyroidism.Prolonged disease duration is more likely to lead to a decrease in lumbar spine BMD.FT3 and FT4 levels are negatively correlated with BMD values.

关 键 词：骨密度 甲状腺激素 甲状腺功能亢进 绝经后女性 相关性 

分 类 号：R965.2[医药卫生—药理学]