血清非高密度脂蛋白胆固醇与非瓣膜性心房颤动的相关性研究  

Serum non-high-density lipoprotein cholesterol concentration and non-valvular atrial fibrillation

作　　者：潘令新[1] 熊恩来[1] 杜慧玲[1] 乔建忠 张斌[1] 严凌[1] PAN Lingxin;XIONG Enlai;DU Huiling;QIAO Jianzhong;ZHANG Bin;YAN Ling(Department of Cardiology,People′s Hospital of Tongling,Tongling 244000,China)

机构地区：[1]铜陵市人民医院心血管内科,安徽铜陵244000

出　　处：《皖南医学院学报》2023年第5期428-430,共3页Journal of Wannan Medical College

基　　金：安徽省重点研究与开发计划项目(2022e07020070)。

摘　　要：目的:探讨血清非高密度脂蛋白胆固醇(non-HDL-C)水平与非瓣膜性房颤之间的相关性。方法:选取2019年10月~2020年12月在铜陵市人民医院心血管内科一病区住院患者113例,其中非瓣膜性房颤患者63例为研究组,其余50例窦性心律患者作为对照组。患者入院后常规检测生化指标,然后计算血清non-HDL-C水平,并收集临床基线资料。结果:研究组患者血清non-HDL-C水平[(2.67±0.88)mmol/L]低于对照组[(3.30±0.90)mmol/L],P<0.05。多因素Logistic回归分析显示,高水平的non-HDL-C(OR=0.450,95%CI:0.272~0.746)是非瓣膜性房颤发生的保护因素(P<0.05);而高水平的血尿酸(OR=1.006,95%CI:1.002~1.010)是非瓣膜性房颤发生的危险因素(P<0.05)。结论:血清non-HDL-C与非瓣膜性房颤的发生关系密切,高水平的non-HDL-C可能是非瓣膜性房颤发生的保护因素。Objective:To investigate the correlation between serum non-high-density lipoprotein cholesterol(non-HDL-C)concentration and non-valvular atrial fibrillation.Methods:One hundred and thirteen hospitalized patients treated in the first Department of Cardiology of Tongling people′s Hospital were included from October 2019 to December 2020,and divided into non-HDL-C group(n=63)and control group(n=50,patients with sinus rhythm).All patients underwent routine measurement of biochemical indexes after admission.The non-HDL-C level was calculated,and clinical baseline data were collected.Results:Patients with non-valvular atrial fibrillation had higher non-HDL-C level than those in the control group[(2.67±0.88)mmol/L vs.(3.30±0.90)mmol/L,P<0.05].Multivariate logistic regression analysis showed that high level of non-HDL-C was a protective factor for non-valvular atrial fibrillation(OR=0.450,95%CI:0.272-0.746),whereas high level of blood uric acid was the risks for non-valvular atrial fibrillation(OR=1.006,95%CI:1.002-1.010,P<0.05).Conclusion:Serum non-HDL-C is closely related to the occurrence of non-valvular atrial fibrillation,and high level of non-HDL-C may be a protective factor for the occurrence of non-valvular atrial fibrillation.

关 键 词：心房颤动 非高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 

分 类 号：R541.75[医药卫生—心血管疾病] R575[医药卫生—内科学]