溶解自身以保护群体:细菌噬菌体防御中的cGAS泛素样偶联机制  

Dissolving self to protect community:cGAS ubiquitin-like mechanism for bacteria to fight against phages

作　　者：王俊轶 李国平 吴敏 Junyi Wang;Guoping Li;Min Wu(Laboratory of Allergy and Precision Medicine,Department of Pulmonary and Critical Care Medicine,Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu,Affiliated Hospital of Southwest Jiaotong University,Chengdu 610000,China;State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao SAR 999078,China;Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China)

机构地区：[1]Laboratory of Allergy and Precision Medicine,Department of Pulmonary and Critical Care Medicine,Chengdu Institute of Respiratory Health,The Third People’s Hospital of Chengdu,Affiliated Hospital of Southwest Jiaotong University,Chengdu 610000,China [2]State Key Laboratory of Quality Research in Chinese Medicine,Macao University of Science and Technology,Macao SAR 999078,China [3]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China

出　　处：《Science Bulletin》2023年第19期2132-2134,M0003,共4页科学通报（英文版）

基　　金：the National Natural Science Foundation of China(81970026,82000029,and 82200079);the National Key Clinical Specialist Construction Project(2023031L);the Natural Science Foundation of Sichuan(2022NSFSC1324 and 23NSFSC1736);the Chengdu High-level Key Clinical Specialty Construction Project(ZX20201202020);Wenzhou Institute,University of Chinese Academy of Sciences.

摘　　要：In a recent paper published in Nature,Jenson et al.[1]reported that CD-NTases-associated protein 2(Cap2)regulates the activity of bacterial cyclic GMP-AMP synthase(cGAS)-like enzymes in a manner analogous to ubiquitination,boosting the production of the second messenger cyclic GMP-AMP(cGAMP)to enable antiphage immunity.The ubiquitin-like conjugation system serves as a countermeasure to phage evasion strategy that sequesters cGAMP to block downstream phospholipase activation,thereby enhancing bacterial defense(Fig.1)[1].This discovery not only unveils a primitive defense mechanism by modulating bacterial cGAS antiviral activity but also represents a compelling example of the escalating arms race between bacteria and phages,which deepens our insight into viral tactics how to evade cGAS-based host defenses.

关 键 词：细菌噬菌体 BOOSTING thereby 

分 类 号：R378[医药卫生—病原生物学]