Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice  

作　　者：Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang 

机构地区：[1]State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Department of Biochemistry,Peking Union Medical College,Beijing 100005,China

出　　处：《Science China(Life Sciences)》2023年第10期2370-2379,共10页中国科学（生命科学英文版）

基　　金：the National Natural Science Foundation of China(81788101);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-022);the 111 Project(BP0820029);the CAMS Endowment Fund(2021-CAMSJZ001)。

摘　　要：Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension.

关 键 词：HYPERTENSION oligonucleotide drug oral administration 

分 类 号：R285.5[医药卫生—中药学]