维持性血液透析患者PDGF-AA与腹主动脉钙化关系的研究  

Study on relationship between PDGF-AA and abdominal aortic calcification in maintenance hemodialysis patients

作　　者：程坤 孙东 Cheng Kun;Sun Dong(School of Clinical Medicine,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China)

机构地区：[1]徐州医科大学临床学院,江苏徐州221004

出　　处：《齐齐哈尔医学院学报》2023年第15期1412-1418,共7页Journal of Qiqihar Medical University

基　　金：徐州市重点研发计划(KC20160)。

摘　　要：目的 观察维持性血液透析患者(maintenance hemodialysis, MHD)血小板衍生生长因子-aa(Platelet-derived growth factor-aa, PDGF-AA)与腹主动脉钙化情况,探讨PDGF-AA与血管钙化(vascularcalcification, VC)之间的关系。方法 选取2020年7月—2021年7月在徐州医科大学附属医院治疗的MHD患者65例作为研究对象,采用腹主动脉钙化评分(abdominal aortic calcification score, AACs)分为无或轻度钙化组(33例)和中重度钙化组(32例)两组。收集患者一般临床资料及检验资料,ELISIA方法检测PDGF-AA、骨形态发生蛋白-2(Bone Morphogenetic Protein-2,BMP-2)、骨形态发生蛋白-4(Bone Morphogenetic Protein-4,BMP-4)。Spearman相关法分析、Logistic回归法分析AAC的危险因素,受试者工作特征曲线(ROC)评价PDGF-AA预测AAC的准确性。结果 不同钙化组年龄、透析龄、是否糖尿病,血清磷、PDGF-AA、BMP-2、BMP-4、甲状旁腺激素(Parathyroid hormone, PTH)、钙磷乘积存在明显差异(P<0.05)。以PDGF-AA预测患者钙化的ROC曲线分析,曲线下面积为0.772(0.658~0.886)(P<0.05)。结论 MHD患者普遍存在血管钙化,高龄、高血糖、透析时间长、PTH升高、BMP-2升高是引发维持性血液透析患者发生腹主动脉钙化的主要因素,有必要将其作为预测指标,对相关人群提前采取预防干预措施。其PDGF-AA与腹主动脉钙化的相关性呈正相关,可能为血管钙化的预防提供新的思路。Objective To observe the condition of platelet-derived growth factor-aa(PDGF-AA)and abdominal aortic calcification in patients receiving maintenance hemodialysis(MHD),and to explore the relationship between PDGF-AA and vascular calcification(VC).Methods From July 2020 to July 2021,65 patients receiving MHD in the Affiliated Hospital of Xuzhou Medical University were enrolled as study subjects.According to abdominal aortic calcification score(AACS),the patients were divide into two groups:none or mild calcification group,and moderate or severe calcification group.General clinical data and test data of patients were collected.PDGF-AA,Bone Morphogenetic Protein-2(Bmp-2),and Bone Morphogenetic Protein-4(Bmp-4)were detected by ELISA method.Spearman correlation analysis and Logistic regression analysis were used to analyzed risk factors of AAC,receiver operating characteristic curve(ROC)was used to evaluate the accuracy of PDGF-AA in predicting AAC.Results There were significant differences in age,dialysis age,diabetes mellitus or not,serum P,PDGF-AA,BMP-2,BMP-4,parathyroid hormone(PTH),calcium and phosphorus product among different calcification groups(P<0.05).ROC curve analysis for predicting calcification in patients with PDGF-AA,the area under the curve was 0.772(0.658~0.886)(P<0.05).Conclusions Vascular calcification is common in patients with MHD.The main factors that cause abdominal aortic calcification in maintenance hemodialysis patients are advanced age,high blood glucose,long dialysis time,high PTH,high BMP-2.It is necessary to take them as predictive index and take preventive intervention measures in advance for the relevant population.The positive correlation between PDGF-AA and aortic calcification may provide a new way to prevent vascular calcification.

关 键 词：血液透析 PDGF-AA 腹主动脉钙化 相关性 

分 类 号：R446.1[医药卫生—诊断学]