Asymmetric annulations based on cycloisomerization of cyclopropyl tethered allenyl ketones by bimetallic relay catalysis  

作　　者：Jun He Wen Liu Jing Zhang Ziwei Zhong Lili Lin Xiaoming Feng 

机构地区：[1]Key Laboratory of Green Chemistry&Technology,Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China

出　　处：《Science China Chemistry》2023年第10期2803-2809,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21890723,22171189);the Fundamental Research Funds for the Central Universities(YJ201819)。

摘　　要：The diastereo-and enantioselective tandem cycloisomerization/[4+2]-cycloaddition reaction of cyclopropyl tethered allenyl ketones withα,β-unsaturated carbonyl compounds was realized firstly under mild reaction conditions by using bimetallic silver(I)/chiral metal-N,N′-dioxide catalysts,providing a facile and atom-economic route to enantioenriched polysubstituted furopyran derivatives with good results.Possible transition state models were proposed to explain the stereoinduction.

关 键 词：asymmetric catalysis bimetallic relay cyclopropyl tethered allenyl ketones [4+2]-cycloaddition furopyran 

分 类 号：O621.251[理学—有机化学]