Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement  

作　　者：Jian Zhang Jia-Yi Su Yang-Zi Liu Hao Li Quannan Wang Wei-Ping Deng 

机构地区：[1]College of Chemistry and Materials Science,Zhejiang Normal University,Jinhua 321004,China [2]School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Science China Chemistry》2023年第10期2810-2816,共7页中国科学（化学英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFA0804900);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01007);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism。

摘　　要：Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed.The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way.This cascade reaction proceeds under mild conditions with excellent functional group compatibility.Furthermore,the catalytic asymmetric version has also been explored.

关 键 词：PALLADIUM UMPOLUNG allylic alkylation Pudovik addition [1 2]-phospha-Brook rearrangement 

分 类 号：O621.251[理学—有机化学]