Rhodium-catalyzed enantioselective annulation of N-phenoxyacetamides with 1,3-dienes  

作　　者：Hui Yang Zi-Qi Yang Su-Zhen Zhang Wen-Wen Zhang Qing Gu Shu-Li You 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Science China Chemistry》2023年第10期2842-2846,共5页中国科学（化学英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFA1500100);the National Natural Science Foundation of China(21821002,92256302,22071260);the Science and Technology Commission of Shanghai Municipality(21520780100)。

摘　　要：Chiral dihydrobenzofuran is a valuable synthetic fragment in both medicinal and organic chemistry.Efficient rhodium(Ⅲ)-catalyzed chemoselective and enantioselective C-H functionalization/[3+2]annulation of N-phenoxyacetamides with 1,3-dienes is reported.In the presence of 5 mol%Cp Rh complex,various chiral dihydrobenzofurans were synthesized in up to 79%yield and 98%ee.This reaction proceeds under mild conditions with excellent functional group compatibility.

关 键 词：asymmetric catalysis C-H functionalization rhodium catalysis chiral dihydrobenzofuran 

分 类 号：O621.251[理学—有机化学]