人干扰素α2b喷雾剂治疗儿童疱疹性咽峡炎的临床疗效及对炎性反应的影响  

Clinical efficacy of recombinant human interferon α2b spray in the treatment of herpetic angina in children and its impact on inflammatory response

作　　者：杨雪梅 YANG Xuemei(Changsha Central Hospital Affiliated to Nanhua University,Changsha 410000,China)

机构地区：[1]南华大学附属长沙中心医院,长沙市410000

出　　处：《临床合理用药杂志》2023年第30期29-32,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨人干扰素α2b喷雾剂治疗儿童疱疹性咽峡炎的疗效及对炎性反应的影响。方法选取2021年6月—2022年11月南华大学附属长沙中心医院收治的疱疹性咽峡炎患儿68例为研究对象,根据随机数字表法分为利巴韦林组与人干扰素α2b组,各34例。利巴韦林组采用利巴韦林喷雾剂治疗,人干扰素α2b组采用人干扰素α2b喷雾剂治疗,2组均治疗7 d。比较2组临床疗效,症状消退时间,治疗前及治疗7 d后血清炎性因子[白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平、T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及不良反应。结果人干扰素α2b组总有效率高于利巴韦林组(94.12%vs.76.47%,χ^(2)=4.221,P=0.040)。人干扰素α2b组退热时间、口腔疱疹消失时间、咽部疱疹消失时间、进食恢复时间短于利巴韦林组(P<0.05或P<0.01)。治疗7 d后,利巴韦林组血清IL-10、CRP水平低于治疗前,人干扰素α2b组血清IL-10、TNF-α、CRP水平低于治疗前,且人干扰素α2b组低于利巴韦林组(P<0.01);2组CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于治疗前,且人干扰素α2b组升高/降低幅度大于利巴韦林组(P<0.01)。人干扰素α2b组与利巴韦林组不良反应总发生率比较,差异无统计学意义(5.88%vs.8.82%,P=1.000)。结论人干扰素α2b喷雾剂治疗儿童疱疹性咽峡炎可快速减轻患儿的临床症状,减轻机体炎性反应并改善免疫功能,增强疗效,且安全性较高。Objective To investigate the clinical efficacy of recombinant human interferonα2b spray in the treatment of herpetic angina in children and its impact on inflammatory response.Methods Sixty-eight cases of children with herpetic angina admitted to Changsha Central Hospital Affiliated to Nanhua University from June 2021 to November 2022 were selected for the study,and they were divided into the ribavirin group and the interferon group according to random number table method,34 cases in each group.The ribavirin group was treated with ribavirin spray,and the interferon group was treated with recombinant human interferonα2b spray,both groups were treated for 7 days.Clinical efficacy,symptom regression time,serum levels of inflammatory factors(IL-10,TNF-α,CRP),T-cell subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))before and after 7 days of treatment,and incidence of adverse reactions of the two groups were compared.Results The total effective rate of the interferon group was higher than that of the ribavirin group(94.12%vs.76.47%,χ^(2)=4.221,P=0.040.Fever reduction time,disappearance time of oral herpes and pharyngeal herpes,and feeding recovery time of the interferon group were shorter than those of the ribavirin group(P<0.05 or P<0.01).After 7 days of treatment,serum levels of IL-10 and CRP of the ribavirin group were lower than those before treatment,serum levels of IL-10,TNF-α,CRP of the interferon group were lower than those before treatment,and serum levels of IL-10,TNF-α,CRP of the interferon group were lower than those of the ribavirin group(P<0.01);CD4^(+)and CD4^(+)/CD8^(+)of the two groups were higher than those before treatment,and CD8^(+)was lower than that before treatment,and the increase/decrease magnitude of the interferon group was greater than that of the ribavirin group(P<0.01).The difference in the total incidence of adverse reactions between the interferon group and the ribavirin group was not statistically significant(5.88%vs.8.82%,P=1.000).Conclusion Recombinant human interferonα2b spray can qui

关 键 词：疱疹性咽峡炎 儿童 人干扰素α2b喷雾剂 利巴韦林 炎性反应 T淋巴细胞亚群 

分 类 号：R766.12[医药卫生—耳鼻咽喉科]