中药治疗孕期IgG抗A(B)抗体效价升高45例的回顾性分析  

Retrospective Analysis of Chinese Medicine in the Treatment of Elevated Anti-IgG A(B)during Gestation Period for 45 Cases

作　　者：田苗 王秀 韩林 孙成才 庞永红 TIAN Miao;WANG Xiu;HAN Lin;SUN Chengcai;PANG Yonghong(Comprehensive Outpatient Department,Xuzhou Maternity and Child Health Care Hospital,Jiangsu Province,Xuzhou 221009,China;Department of Pediatrics,Xuzhou Maternity and Child Health Care Hospital,Jiangsu Province,Xuzhou 221009,China)

机构地区：[1]徐州医科大学附属徐州市妇幼保健院综合科,江苏徐州221009 [2]徐州医科大学附属徐州市妇幼保健院儿科,江苏徐州221009

出　　处：《中国中医药现代远程教育》2023年第22期89-92,共4页Chinese Medicine Modern Distance Education of China

基　　金：徐州市科技计划社会发展项目【No.KC20081】。

摘　　要：目的通过回顾性分析探讨中药治疗孕期IgG抗A(B)抗体效价升高的有效性和安全性。方法收集接受中药治疗的孕期IgG抗A(B)抗体效价升高患者45例,总结治疗后患者抗体效价、妊娠结局,新生儿体质量、新生儿Apgar评分、溶血及黄疸情况,治疗过程中中药相关肝肾功能损害及对胎儿产生致畸作用的情况等。结果治疗后抗体效价下降22例,升高5例,未变13例,5例未随访抗体效价,其中1例抗体效价升高的患者胎儿血型为O型,与母亲血型一致;新生儿黄疸发生率20.00%(9/45),其中溶血性黄疸发生率13.33%(6/45),发生黄疸新生儿中母亲IgG抗B抗体阳性占比较高,约为66.67%(6/9);治疗过程未发现明显中药相关肝肾功能损害及对胎儿产生致畸作用情况。结论中药可在一定程度上降低IgG抗A(B)抗体效价,降低新生儿黄疸的发生率,无明显不良反应且无胎儿致畸作用;新生儿黄疸的发生可能与母亲IgG抗体类型有一定的相关性;孕期IgG抗A(B)抗体效价的升高不能作为判断母儿血型不合的依据。Objective To explore the efficacy and safety of Chinese medicine in the treatment of elevated Anti-IgG A(B)during gestation period.Methods Clinical data of 45 patients with elevated Anti-IgG A(B)during gestation period treated by Chinese medicine was collected including anti-IgG A(B)titers,pregnancy outcome,the weight,Apgar score,hemolysis and jaundice of newborns after treatment.Results 22 cases anti-IgG A(B)titers decreased,5 cases increased and 13 cases remained unchanged after treatment.The incidence of neonatal jaundice and neonatal hemolysis was 20%(9/45)and 13.33%(6/45),respectively.The positive rate of Anti-IgG B was 66.67%(6/9)in newborns with jaundice accepted treatment.One patient with elevated antibody titer blood type was the same with the baby,both of them was O.No obvious damages of liver and kidney function and fetal malformation were found.Conclusion Chinese medicine can decrease the titers of anti-IgG A(B)without obvious side effects and fetus teratogenicity.The maternal antibody type may be correlated with the occurrence of neonatal jaundice.The elevated Anti-IgG A(B)during gestation period can’t be the evidence to diagnose maternal-fetal blood group incompatibility.

关 键 词：胎黄 ABO血型不合 中医药疗法 回顾性分析 

分 类 号：R271.9[医药卫生—中西医结合]