急性肺栓塞患者肌钙蛋白I、半胱氨酸蛋白酶抑制剂C及肌酸激酶同工酶的表达及临床意义  

Expression and clinical significance of troponin I,cystatin C and creatine kinase isoenzyme in patients with acute pulmonary embolism

作　　者：李春玉 薛启婷 李跃 LI Chun-yu;XUE Qi-ting;LI Yue(Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京世纪坛医院,北京100038 [2]首都医科大学附属友谊医院,北京100050

出　　处：《实用医院临床杂志》2023年第6期92-95,共4页Practical Journal of Clinical Medicine

基　　金：北京市优秀人才培养资助项目(编号:20180000214690258)。

摘　　要：目的分析急性肺栓塞(APE)患者肌钙蛋白I(cTnI)、半胱氨酸蛋白酶抑制剂C(Cys-C)及肌酸激酶同工酶(CK-Mb)的表达及临床意义。方法选取2019年2月至2021年7月在北京世纪坛医院就诊的APE患者112例(试验组),选取同期健康体检结果正常者98例为对照组。对APE患者随访6个月,根据预后评判标准分为预后良好组88例和预后不良组24例,对比两组cTnI、Cys-C及CK-Mb水平;分析APE患者预后的影响因素;cTnI、Cys-C及CK-Mb联合检测对APE预后的预测价值。结果试验组cTnI、Cys-C及CK-Mb水平高于对照组(P<0.05);随访结束,预后不良组cTnI、Cys-C及CK-Mb水平高于预后良好组(P<0.05);吸烟史、高血压、糖尿病、右心室功能不全以及cTnI、Cys-C、CK-Mb水平异常升高是APE患者预后的影响因素(P<0.05);cTnI、Cys-C及CK-Mb联合检测AUC曲线下面积为0.967,大于三者单独检测(P<0.05)。结论cTnI、Cys-C及CK-Mb水平是影响APE患者预后的相关因素,对患者预后评估具有重要意义。Objective To analyze the expression and clinical significance of cardiac troponin I(cTnI),cystatin-C(Cys-C)and creatine kinase isoenzyme(CK-Mb)in patients with acute pulmonary embolism(APE).Methods One hundred and twelve APE patients who were treated in the Beijing Shijitan Hospital from February 2019 to July 2021 were selected as a research group.At the same time,98 subjects who had normal physical examination results in our hospital were selected as a control group.The APE patients were followed up for 6 months,and the patients were divided into a good prognosis group(n=88)and a poor prognosis group(n=24)according to the prognostic criteria.The levels of cTnI,Cys-C and CK-Mb were compared between the good prognosis group and the poor prognosis group.The related factors affecting the prognosis of patients with APE were analyzed.The predictive value of the combined detection of cTnI,Cys-C and CK-Mb on the prognosis of APE was analyzed.Results The levels of cTnI,Cys-C and CK-Mb in the research group were significantly higher than those in the control group(P<0.05).At the end of the follow-up,the levels of cTnI,Cys-C and CK-Mb in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).Smoking history,hypertension,diabetes,right ventricular insufficiency and abnormally elevated levels of cTnI,Cys-C and CK-Mb were related factors affecting the prognosis of patients with APE(P<0.05).The area under the ROC curve(AUC)of the combined detection of cTnI,Cys-C and CK-Mb was 0.967,which was greater than that of the three alone(P<0.05).Conclusions The levels of cTnI,Cys-C and CK-Mb are related factors affecting the prognosis of patients with APE.They are of great significance for the prognosis evaluation in APE patients.

关 键 词：急性肺栓塞 肌钙蛋白I 半胱氨酸蛋白酶抑制剂C 肌酸激酶同工酶 

分 类 号：R563.9[医药卫生—呼吸系统]