莪术醇片剂的制备及大鼠在体肠吸收研究  

Prescription selection and in vivo intestinal absorption of curcumol tablets

作　　者：李林峻 刘国翔 刘张驰 王炎 张玮[1] 王娟[1,2] LI Lin-jun;LIU Guo-xiang;LIU Zhang-chi;WANG Yan;ZHANG Wei;WANG Juan(Laboratory of Pharmacognosy,College of Pharmacy,Guilin Medical University,Guilin Guangxi 541199;Faculty of Basic Medicine,Guilin Medical University,Guilin Guangxi 541199)

机构地区：[1]桂林医学院药学院生药学重点实验室,广西桂林541199 [2]桂林医学院药学院基础医学院,广西桂林541199

出　　处：《中南药学》2023年第10期2654-2658,共5页Central South Pharmacy

基　　金：广西科技计划项目(桂科ZD20302006);国家自然科学基金项目(No.81760663,No.82160768,No.82002822);中国博士后科学基金项目(No.2020M683630XB)。

摘　　要：目的探索莪术醇片剂的处方及其在大鼠体内的小肠动力学特征。方法采用湿法制粒压片法制备莪术醇片剂,通过单因素实验筛选处方,并测定体外累计溶出度,考察药物释放情况;通过大鼠在体肠循环实验,比较莪术醇原料药和片剂在大鼠小肠中的吸收情况。结果筛选出莪术醇片剂的适宜处方为莪术醇2 g、羟丙甲纤维素0.225 g、玉米淀粉1.5 g、硬脂酸镁0.225 g、一水合乳糖11.05 g。片剂在溶出介质中60 min的溶出度大于80%。莪术醇片剂在大鼠小肠中的吸收速率高于莪术醇原料药。结论莪术醇片剂组成合理,工艺简单,体外累计溶出速率符合要求。与莪术醇原料药相比,莪术醇片剂能改善大鼠的小肠吸收。Objective To explore the formulation of curcumol tablets and the dynamic characteristics of small intestine in rats.Methods Curcumol tablets were prepared with wet granule compression.The formulation was screened with single factor experiment,and the cumulative dissolution in vitro was measured to determine the drug release,based on the experiment of in situ method in rats.The absorption of curcumol and its tablets in the small intestine of rats was compared.Results The suitable formulation of curcumol tablets included 2 g curcumol,0.225 g hydroxypropyl methylcellulose,1.5 g corn starch,0.225 g magnesium stearate and 11.05 g lactose monohydrate.The dissolution rate of the tablets in the dissolution medium for 60 min was over 80%.The absorption rate of curcumol tablets in the small intestine of rats was higher than that of curcumol raw material.Conclusion The composition of curcumol tablets is reasonable,the process is simple,and the cumulative dissolution rate in vitro meets the requirements.In comparison to curcumol raw material,curcumol tablets can promote the intestinal absorption in rats.

关 键 词：莪术醇 片剂 单因素实验 溶出度 在体肠循环 

分 类 号：R943.4[医药卫生—药剂学] R283[医药卫生—药学]