血清HMGB1与COPD急性加重期患者炎性指标肺功能参数之间的相关性  

Correlation between Serum HMGB1 and Inflammatory Indicators and Lung Function Parameters in Patients with Acute Exacerbation of COPD

作　　者：唐文君[1] 曾珠 杨帆[2] 肖玮[1] TANG Wenjun;ZENG Zhu(The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu 610072,China)

机构地区：[1]成都中医药大学附属医院呼吸内科,四川成都610072 [2]成都医学院第一附属医院呼吸与危重医学科,四川成都610500

出　　处：《河北医学》2023年第10期1649-1654,共6页Hebei Medicine

基　　金：四川省科学技术厅项目,(编号:2022YFS0423);成都市科学技术局项目,(编号:2021-YF05-02035-SN)。

摘　　要：目的:分析血清高迁移率族蛋白1(HMGB1)与急性加重期慢性阻塞性肺疾病(AECOPD)患者炎性指标、肺功能参数之间的相关性。方法:从2020年1月至2022年6月到我院就诊的AECOPD患者中选取104例纳入AECOPD组;从就诊的稳定期慢性阻塞性肺疾病(COPD)患者中选取104例纳入COPD组;从同期健康体检者中选取104例那纳入健康对照组。比较各组入院时的外周血相关指标[HMGB1、缺氧诱导因子1α(HIF-1α)、白细胞计数(WBC)]水平、血清炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)]水平及肺功能参数[6min步行距离(6MWD)、肺动脉压、二氧化碳分压(PaCO_(2))、氧分压(PaO_(2))];分析血清HMGB1与上述炎性指标及肺功能参数的关系。结果:三组入院时的血清HMGB1、HIF-1α、IL-6、CRP、PCT水平及WBC均表现为AECOPD组>COPD组>健康对照组,组间比较差异有统计学意义(P<0.05)。三组入院时的6MWD值及PaO_(2)水平均表现为AECO-PD组<COPD组<健康对照组,组间比较差异有统计学意义(P<0.05)。三组入院时的肺动脉压、PaCO_(2)水平均表现为AECOPD组>COPD组>健康对照组,组间比较差异有统计学意义(P<0.05)。Pearson相关性分析显示,AECOPD患者入院时的血清HMGB1水平与IL-6、CRP、肺动脉压水平呈正相关(r分别=0.566、0.287、0.230,P均<0.05),与PaO2水平呈负相关(r=-0.212,P<0.05)。结论:与稳定期COPD及健康体检者相较,AECOPD患者的血清HMGB1水平异常升高,且与IL-6、CRP、肺动脉压、PaO2水平密切相关。Objective:To analyze the correlation of serum high mobility group protein 1(HMGB1)with inflammatory indicators and pulmonary function parameters in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 104 patients with AECOPD who were treated in the hospital from January 2020 to June 2022 were selected and included in AECOPD group,and another 104 patients with stable chronic obstructive pulmonary disease(COPD)were enrolled as COPD group.104 healthy subjects with physical examination during the same time period were included in healthy control group.The levels of peripheral blood related indicators[HMGB1,hypoxia-inducible factor-1α(HIF-1α),white blood cell count(WBC)]and serum inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT)]and pulmonary function parameters[6-minute walk distance(6MWD),pulmonary artery pressure,partial pressure of carbon dioxide(PaCO_(2)),partial pressure of oxygen(PaO_(2))]were compared among the groups at admission.The relationship between serum HMGB1 and the above inflammatory indicators and pulmonary function parameters was analyzed.Results:The levels of serum HMGB1,HIF-1α,IL-6,CRP,PCT and WBC in the three groups at admission were manifested as AECOPD group>COPD group>healthy control group(P<0.05).The 6MWD and PaO_(2)at admission were shown as AECOPD group<COPD group<healthy control group(P<0.05).The pulmonary artery pressure and PaCO_(2)of the three groups at admission showed AECOPD group>COPD group>healthy control group(P<0.05).Pearson correlation analysis showed that serum HMGB1 level at admission was positively correlated with IL-6,CRP and pulmonary artery pressure in patients with AECOPD(r=0.566,0.287,0.230,all P<0.05),and was negatively correlated with PaO_(2)(r=-0.212,P<0.05).Conclusion:Compared with patients with stable COPD and healthy subjects,serum HMGB1 level in patients with AECOPD is abnormally increased,and serum HMGB1 is closely related to IL-6,CRP,pulmonary artery pressure and PaO_(2).

关 键 词：慢性阻塞性肺疾病 急性加重期 血清高迁移率族蛋白1 肺功能 相关性 

分 类 号：R563.9[医药卫生—呼吸系统]