以环孢素A为主的复方用药方案治疗非重型再生障碍性贫血疗效分析  

Analysis of the Efficacy of Cyclosporin A-based Compound Medication Regimen in the Treatment of Non-Severe Aplastic Anemia

作　　者：卫淑娟 王晶 吕文艳 李晶晶 WEI Shujuan;WANG Jing;LU Wenyan(Xijing Hospital,The First Affiliated Hospital of Air Force Military Medical University of People's Liberation Army,Shaanxi Xi'an 710032,China)

机构地区：[1]中国人民解放军空军军医大学第一附属医院西京医院血液科,陕西西安710032

出　　处：《河北医学》2023年第10期1730-1734,共5页Hebei Medicine

基　　金：陕西省自然科学基金,(编号:2022JQ-873)。

摘　　要：目的:研究环孢素A联合复方皂矾丸及十一酸睾酮治疗非重型再生障碍性贫血(NSAA)的疗效。方法:以回顾性分析法,观察对象为2020年1月至2023年1月入院的80例NSAA患者,参考治疗方式分为研究组(40例)与对照组(40例),研究组给予环孢素A基础上加用复方皂矾丸和十一酸睾酮治疗,对照组行环孢素A和司坦唑醇治疗;比较两组治疗前后CD4^(+)、CD8^(+)、白细胞计数、血小板计数、血红蛋白水平与治疗后肝功能指标[血清碱性磷酸酶(ALP)、谷氨酰转移酶(GGT)、谷草转氨酶(AST)、谷丙转氨酶(ALT)]水平、总有效率、副作用(毒副作用、肝功能异常)发生率。结果:两组治疗前CD4^(+)、CD8^(+)、白细胞计数、血小板计数、血红蛋白水平差异无统计学意义(P>0.05);较治疗前,两组治疗后CD4^(+)、白细胞计数、血小板计数、血红蛋白水平更高,CD8^(+)更低,差异有统计学意义(P<0.05);较对照组,研究组治疗后CD4^(+)、白细胞计数、血小板计数、血红蛋白水平与总有效率更高,CD8^(+)、ALP、GGT、AST、ALT水平与毒副作用、肝功能异常发生率更低,差异有统计学意义(P<0.05)。结论:在环孢素A治疗基础上联合复方皂矾丸和十一酸睾酮治疗NSAA患者疗效显著,可增强患者细胞免疫功能,改善白细胞、血小板计数与血红蛋白水平,还可降低其肝脏损害程度,副作用小,安全性高。Objective:To study the efficacy of compound Zaofan pills combined with cyclosporine A and testosterone undecanoate in the treatment of non-severe aplastic anemia(NSAA).Methods:A retrospective analysis was performed on 80 patients with NSAA admitted to the hospital from January 2020 to January 2023.According to the treatment methods,they were divided into study group(40 cases)and control group(40 ca-ses).The study group was treated with compound Zaofan pills combined with cyclosporine A and testosterone undecanoate,and the control group was treated with cyclosporine A and stanazolol.The lymphocyte subsets(CD4^(+),CD8^(+)),white blood cell count,platelet count,hemoglobin level before and after treatment,liver function indexes[serum alkaline phosphatase(ALP),glutamyltransferase(GGT),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],total effective rate,side effects(toxic side effects,liver func-tion)were compared between the two groups.Results:There were no significant differences in CD4^(+),CD8^(+),white blood cell count,platelet count and hemoglobin level between the two groups before treatment(P>0.05).Compared with before treatment,CD4^(+),white blood cell count,platelet count and hemoglobin level were higher in the two groups after treatment,and CD8^(+)was lower,the difference was statistically significant(P<0.05).Compared with the control group,the CD4^(+),white blood cell count,platelet count,hemoglobin level and total effective rate of the study group were higher,and the CD8^(+),ALP,GGT,AST,ALT levels and the incidence of toxic side effects and abnormal liver function were lower,the differences were statistically sig-nificant(P<0.05).Conclusion:Compound Zaofan pill combined with cyclosporine A and testosterone unde-canoate is effective in the treatment of patients with NSAA,which can enhance the cellular immune function,improve white blood cell count,platelet count and hemoglobin level,and reduce the degree of liver damage,with few side effects and high safety.

关 键 词：非重型再生障碍性贫血 复方皂矾丸 环孢素A 十一酸睾酮 司坦唑醇 

分 类 号：R556.5[医药卫生—血液循环系统疾病]