人源Cathelicidins家族抗菌肽LL-37生物学功能和分子修饰研发进展  

Advance on human Cathelicidins antimicrobial peptide LL-37 in bio-logical function and molecular modification

作　　者：邵长轩 赵光辉 朱永杰 于伟康 关红蕊 单安山[1] SHAO Changxuan;ZHAO Guanghui;ZHU Yongjie;YU Weikang;GUAN Hongrui;SHAN Anshan(School of Animal Sciences and Technology,Northeast Agricultural University,Harbin 150030,China)

机构地区：[1]东北农业大学动物科学技术学院,哈尔滨150030

出　　处：《东北农业大学学报》2023年第7期80-90,共11页Journal of Northeast Agricultural University

基　　金：黑龙江省自然科学基金优秀青年项目(YQ2022C015);中国博士后科学基金资助项目(2022M720694);国家自然科学基金项目(32272914)。

摘　　要：抗生素过度或不当使用导致细菌耐药性增强、环境生态恶化等问题日益严重。抗菌肽(Antimicrobial peptides,AMPs)因具有广谱抗菌活性及不易产生耐药性的膜溶解式抑菌机理被广泛研究。作为人体中唯一的Cathelicidins家族AMP,LL-37具有抗菌、抗病毒、抗生物被膜和免疫调节等功能,可帮助机体有效预防炎症、抵御病原体入侵,开发潜力巨大。通过综述LL-37表达和已发现的生物学功能,梳理其产业化进程中的阻碍和分子改造策略,以期为基于LL-37的新药临床、非营养性饲料添加剂创制和表面防腐剂研发提供新思路。In the context of excessive and inappropriate use of antibiotics,problems such as increased antibiotic resistance of bacteria and the deterioration of ecological environment are becoming increasingly serious.Antimicrobial peptides(AMPs)have been widely studied because of their broad-spectrum antibacterial activity and membrane-lytic antibacterial mechanism which is not easy to produce drug resistance.As the only Cathelicidins family AMP in humans,LL-37 has various functions such as antibacterial,antifungal,antiviral,antibiofilm and immune regulation,which can effectively prevent inflammation and resist pathogen infections.Here,the expression and biological functions of LL-37 were described.The obstacles in the process of industrialization and molecular modification strategies were also sorted out.The content obtained here could provide novel ideas for the clinical application of new drugs,the creation of non-nutritious feed additives,and the development of surface preservatives based on LL-37.

关 键 词：抗菌肽 CATHELICIDINS LL-37 生物学功能 分子改造 

分 类 号：S816.75[农业科学—饲料科学]